高脂血症中医辨证分型与相关性检验指标的研究

Study on relationship between hyperlipidemia syndrome differentiation of traditional Chinese medicine and its correlation medical test index

目的 探讨高脂血症患者中医辨证分型与年龄、性别、体质量指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白-胆固醇（LDL-C）、高密度脂蛋白-胆固醇（HDL-C）、载脂蛋白ApoAI、ApoB、血管介质、凝血及炎性指标的相关性.方法 从高干病房收集高脂血症患者200例,按照《中药新药临床研究指导原则》高脂血症的中医辨证分型标准,逐一分析与年龄、性别、BMI、TC、TG、LDL-C、HDL-C、载脂蛋白ApoAI、ApoB、血管介质、凝血及炎性指标的关系,并采用SPSS16.0统计软件进行分析.结果 ①各型的年龄、性别、体重指数、TC、TG、HDL-C、LDL-C、VLDL-C、脂蛋白、血管介质、炎性介质及凝血指标比较,差异无统计学意义.②与肝肾阴虚证比较,气滞血郁证、痰浊阻遏证及阴虚阳亢证组载脂蛋白A值高于肝肾阴虚证组（P＜0.05）,差异有统计学意义；载脂蛋白B各型无差异.结论 高脂血症的中医证型与年龄、性别、体重指数、血脂、凝血等指标无关.

Objective To investigate the relationship between TCM syndrome of hyperlipidemia and indexes such as age,sex,BMI,TC,TG,LDL-C,HDL-C,ApoA,ApoB,the vascular media,coagulation and inflammatory indices.Methods 200 patients of hyperlipidemia recruited from the cadre ward in hospital were made TCM syndrome differentiation according to Guiding principles for the clinical study of Chinese Medicines.SPSS16.0 statistical software were adopted for analyzing the relation between TCM syndrome and indexes such as age,sex,BMI,TC,TG,LDL-C,HDL-C,ApoA,ApoB,the vascular media,coagulation and inflammatory indices.Results ①）There are no differences TCM syndrome and the indexes of age,sex,TC,TG,HDL-C,LDL-C,VLDL-C,lipoproteins,the vascular media,coagulation and inflammatory indices.②Compared with the liver kidney yin deficiency syndrome group,apolipoprotein A was higher in the groups of qi stagnation and blood stasis,phlegm stagnation syndrome,and hyperactivity of Yang due to yin deficiency syndrome,the difference was statistically significant; while APOB showed no difference among the groups.Conclusion TCM syndrome of hyperlipidemia had no relation to indexes of age,sex,body mass index,blood lipid,and blood coagulation.The study found a correlation between hyperlipidemia and phlegm and Qi deficiency,which can provide a the oretical basis for syndrome differentiation of TCM.