益肺饮联合介入治疗对老年中晚期非小细胞肺癌血清D-二聚体、CEA、CRP的影响

Effects of Yifei decoction combined with interventional treatment on serum DD,CEA,and CRP levels in elderly patients with advanced non-small cell lung cancer

目的:观察益肺饮在联合介入治疗中对老年中晚期非小细胞肺癌血清D-二聚体、血清C反应蛋白(CRP)、癌胚抗原(CEA)的影响。方法:将60例老年中晚期非小细胞肺癌患者随机分成治疗组和对照组各30例,对照组采用单纯介入治疗,治疗组在对照组治疗基础上加服益肺饮,28d为1个疗程,连续服用2个疗程。结果:治疗组在降低患者血清D-二聚体、CRP、CEA水平方面均优于对照组,两组比较,差异有统计学意义(P<0.05)。结论:益肺饮联合介入治疗可在一定程度上改善老年中晚期非小细胞肺癌患者血液的高凝状态、降低肿瘤负荷,并有望达到改善预后、延长生存期的目的。

Objective: To observe the effects of Yifei decoction combined with interventional treatment on serum levels of D-dimer( DD),C-reactive protein( CRP),and carcinoembryonic antigen( CEA) in elderly patients with advanced non-small cell lung cancer( NSCLC). Methods: Sixty elderly patients with advanced NSCLC were randomly divided into treatment group( n = 30) and control group( n = 30). The control group received interventional treatment alone,while the treatment group was orally given Yifei decoction in addition to interventional treatment. Both groups received treatment for two courses( 28 d per course). Results: The treatment group showed significantly higher decreases in serum DD,CRP,and CEA levels than the control group( P < 0. 05). Conclusion: Yifei decoction combined with interventional treatment can,to a certain extent,reduce the hypercoagulability of blood and tumor burden in elderly patients with advanced NSCLC and may improve prognosis and prolong survival.