两种剂量米非司酮治疗子宫壁间肌瘤的临床效果研究

Study on the Clinical Effects of Two Doses of Mifepristone in Treating Uterine Leiomyoma

目的:研究两种剂量米非司酮对子宫壁间肌瘤患者进行治疗的临床效果,探讨剂量与疗效的关系。方法:随机抽取笔者所在医院门诊和住院部收治的已确诊子宫壁间肌瘤患者89例,将其随机分为大剂量组和小剂量组,采用25 mg/d的剂量对大剂量组进行治疗;采用12.5 mg/d的剂量对小剂量组患者进行治疗。比较两组患者治疗前后的子宫大小、肌瘤大小、血清FSH水平、血清LH水平、血E2水平。结果:小剂量组及大剂量组治疗后子宫及子宫肌瘤体积均小于治疗前(P<0.05),但两剂量组治疗前及治疗后比较差异均无统计学意义(P>0.05);小剂量组与大剂量组治疗前后FSH、LH、E2水平比较差异均有统计学意义(P<0.05);治疗后组间FSH水平比较差异有统计学意义(P<0.05)。结论:应用小剂量和大剂量米非司酮对患有子宫壁间肌瘤的患者进行治疗的临床效果统计学无显著性差异,但出于安全及副作用的考虑,笔者推荐低剂量,本次研究由于经费时间限制,长时间的治疗效果有待进一步研究。

Objective：To study the clinical effect of two doses of mifepristone in treatment of uterine intramural myoma patients,to explore the relationship between dose and effect.Method：89 cases of uterine intramural myoma were randomly selected in outpatient and inpatient department of our hospital,which were randomly divided into large dose group（44 cases） and small dose group（45 cases）,the 25 mg/d dose treatment of large dose group;the 12.5 mg/d dose for the treatment of patients with small dose group.Two groups were compared before and after treatment of uterine size,size of tumor,serum FSH level,serum LH level, serum E2 level by statistical analysis,judging curative effect.Result：Low dose group and high dose group after treatment of uterus and uterine myoma volume was less than before treatment（P〈0.05）,but there were no statistically significant difference between the two groups before and after treatment（P〉0.05）;and before and after treatment LH,FSH,E2 level showed significant differences（P〈0.05）in low dose group and high dose group;a statistical significance in comparison to the FSH level difference between the two groups after treatment（P〈0.05）.Conclusion：Application of low dose and high dose mifepristone had no significant difference with uterine intramural myoma patients in the clinical effect,but from the superior efficacy and safety concern we recommended use low does,long term effect need to more research.