黄药子的化学成分研究

Research of Chemical Composition of Dioscorea bulbifera L.

目的:对薯蓣科植物黄药子(Dioscorea bulbifera L.)块茎进行化学成分研究。方法:95%乙醇提取物经系统溶剂萃取后,得到的氯仿萃取部分,应用硅胶柱色谱、高效液相色谱和重结晶等方法进行分离纯化,通过波谱解析进行结构鉴定。结果:从中分离得到5个化合物,根据理化性质和谱学分析鉴定为黄独乙素(diosbulbin-B,Ⅰ),β-扶桑甾醇(β-rosasterol,Ⅱ),β-谷甾醇(β-sitosterol,Ⅲ),(S)5乙基-8,8-二甲基壬醛((S)-5-Ethyl-8,8-dimethyl nonanal,Ⅳ),2,3-Dihydroxyicosanoic酸(2,3-Dihydroxyicosanoic acid,Ⅴ)。结论:化合物(Ⅱ)、(Ⅳ)、(Ⅴ)为首次从黄药子中分离得到的已知化合物。

Objective：To study the chemical constituents of the rhizome of Dioscorea bulbifera L..Methods：Five compounds were isolated and purified by chromatographic column of silica gel,recrystallization and other methods.Their structures were identified by spectral analysis.Results：Five compounds were isolated from the chloroform extraction parts of Dioscorea bulbifera L.,which were diosbulbin-B（Ⅰ）,β-rosasterol（Ⅱ）,β-sitosterol（Ⅲ）,（S）-5-Ethyl-8,8-dimethyl nonanal（Ⅳ）.Conclusion：Compounds（Ⅱ）,（Ⅳ）,（Ⅴ） are found for the first time in Dioscorea plant.