低分子肝素不同剂量对普胸外科患者术后凝血功能的影响

The Influence of Different Doses of Low Molecular Weight Heparin on Coagulation Function in Post Thorax Surgical Patients

目的:低分子肝素的不同剂量对普胸外科患者术后凝血功能变化的影响。方法:选取普胸外科临床有效病例122例,随机分为对照组和术后注射不同剂量低分子肝素(LMWH)的试验Ⅰ组、Ⅱ组、Ⅲ组。观察患者术前和术后活化的部分凝血活酶时间(APTT)、凝血酶原时间(PT)、D-二聚体(D-D)、血小板计数(PLT)及纤维蛋白原(Fib)等指标,比较组间、组内的差异。结果:术后各组PT、APTT延长,Fib、D-D升高,PLT第3天降低而术后第5天开始升高,与术前比较差异有统计学意义(P<0.05)。结论:固定剂量(4250 U)的LMWH对改善术后高凝状态具有重要意义。

Objective： To compare the influence of different doses of low molecular weight heparin on blood coagulation system of patients who had＇received thoracic surgery. Method： A total of 122 thoracic post-operative cases were randomly divided into experimental and control groups. The patients in the experimental group were subjected to subcutaneous injection of LMWH on the postoperative. Preoperative and postoperative changes in activated partial thromboplastin time （ APTT ）, prothrombin time （ PT ）, D-dimer （ D-D ）, plate-let count （ PLT ） and fibrinogen （ Fib ） and compared in intra-ancl inter-groups. Result： PT and APTF in each group was prolonged, Fib and D-D increased, PLT reduced on the 3rd day but then increased on the 5th day, with the difference being significant pre-and post-operation （ P〈0.05 ） . Conclusion： Fixed-close （ 4250 U ） of LMWH is able to improve postoperative hypercoagulable state.