雾化吸入沙丁胺醇、布地奈德、异丙托溴铵治疗老年支气管哮喘急性发作期临床疗效分析

Analysis of Clinical Efficacy of Nebulized Salbutamol,Budesonide,Ipratropium Bromide in the Treatment of Acute Exacerbation of Bronchial Asthma in the Elderly

目的:探讨分析雾化吸入沙丁胺醇、布地奈德与异丙托溴铵治疗老年支气管哮喘急性发作期的临床效果。方法:选取2009年1月-2012年1月在本院住院治疗的老年支气管哮喘急性发作期患者90例,将其随机分为对照组45例和治疗组45例。对照组采用常规治疗加用沙丁胺醇雾化吸入,治疗组在常规治疗的基础上加用沙丁胺醇、布地奈德与异丙托溴铵联合雾化吸入。其中沙丁胺醇1 mL/次,3次/d;布地奈德和异丙托溴铵各2 mL/次,2次/d,两组疗程均为10 d。比较两组患者治疗前后PaO2、PaCO2、SaO2、FEV1、FEV1/FVC以及两组间治疗后差异。结果:治疗10 d后,两组上述治疗后均较治疗前有改善,比较差异均有统计学意义(P<O.05)。治疗组疗效较对照组优,差异有统计学意义(P<0.05)。结论:雾化吸入沙丁胺醇、布地奈德与异丙托溴铵治疗老年支气管哮喘急性发作期的临床效果方面具有起效快、疗效好等优势。

Objective： To investigate the clinical effect of budesonidc and salbutamol, ipratropium bromide in the treatment of acute exacerbation of bronchial asthma in the elderly.Method： From January 2009 to January 2012 in the treatment of 90 elderly patients with acute attack of bronchial asthma were randomly divided into the control group for 45 cases and treatment group for 45 cases in our hospital.The control group was treated with conventional treatment plus inhaled salbutamol, the treatment group based on routine treatment combined with budesonide and salbutamol, ipratropium bromide combined inhalation.The salbutamol 1 ml each time, 3 times/day; budesonide combined with ipratropium bromide each 2 ml, 2 times/day, two groups were treated for 10 days.Two groups were compared before and after treatment of PaOz, PaCO2, SaO~ and FEV1, FEV1/FVC, and the differences between the two groups after treatment.Result： Ten days after treatment, the two groups after treatment than before treatment improved （P〈0.05） .The efficacy of the treatment group was better than the control group （ P〈0.05 ） .Conclusion： Inhalation of budesonide and salbutamol, ipratmpium bromide in treatment of elderly patients with acute exacerbation of bronchial asthma clinical effect has the advantages of quick effect, good curative effect and other advantages.