摘要
目的研究应用不同剂量甘露醇治疗老年急性大面积脑梗死的疗效及不良反应。方法选择114例经颅脑CT或MRI确诊的老年脑梗死患者,梗死面积>3cm2,随机分为小剂量组和大剂量组,分别给予不同剂量甘露醇治疗,比较2组临床疗效及安全性。结果小剂量组和大剂量组患者总有效率分别为60.3%、60.7%,2组相比差异无统计学意义(P>0.05)。小剂量组相关并发症少于大剂量组,2组相比差异有统计学意义(P<0.05)。结论使用小剂量甘露醇在保证治疗效果情况下,能明显减少电解质紊乱及脑水肿加重等不良反应,值得临床推广。
Objective To study the efficacy of adverse reaction of different dosages of mannitol in the treatment of elderly patients with acute large area cerebral infarction occurred. Methods Totally 114 elderly patients with cerebral infarction diagnosed by craniocerebral CT or MRI were selected, and the infarction area was greater than 3 cm2. They were randomly divided into low dose group and high dose group, and were given different dosages of mannitol, respectively. The clinical efficacy and safety in patients of the two groups were compared. Results The efficacy of low dose group and high dose group after treat- ment was 60.3% and 60.7~, respectively, there was no significant difference (P^0.05). The complications of the low dose group were fewer than the large dose group, both of them were compared, the difference was statistically significant (P〈0.05). Conclusion Small dosages of mannitol in the treatment of acute large area cerebral infarction, can significantly reduce the electrolyte disorder and brain edema aggravated, it is worthy of clinical promotion.
出处
《中国实用神经疾病杂志》
2013年第19期33-34,共2页
Chinese Journal of Practical Nervous Diseases
关键词
甘露醇
脑梗死
不良反应
Mannitol
Cerebral infarction
Adverse reaction