盐酸多奈哌齐与尼莫地平治疗血管性痴呆认知功能损伤疗效分析

Comparison of clinical efficacy of donepezil hydrochloride and nimodipine on cognitive impairment of vascular dementia

目的探讨盐酸多奈哌齐和尼莫地平治疗血管性痴呆认知功能损伤的临床疗效。方法选取2009-02—2012-06我院收治的84例血管性痴呆患者,随机分成2组,盐酸多奈哌齐组和尼莫地平组,每组42例。盐酸多奈哌齐组患者采用盐酸多奈哌齐口服,尼莫地平组给予尼莫地平口服,均治疗12周。治疗结束后比较2组患者的认识功能改善情况。结果 2组患者治疗后得分均高于治疗前得分,治疗前后数据比较差异均有统计学意义(P<0.05);盐酸多奈哌齐组患者治疗后得分明显高于尼莫地平组,2组比较差异有统计学意义(P<0.05)。盐酸多奈哌齐组总有效率为95.2%,尼莫地平组为76.2%,盐酸多奈哌齐组治疗效果明显优于尼莫地平组,2组比较差异有统计学意义(P<0.05)。结论盐酸多奈哌齐和尼莫地平均可改善血管性痴呆认知功能损失症状,盐酸多奈哌齐的治疗效果优于尼莫地平,安全有效,值得临床推广应用。

Objective To compare clinical efficacy of donepezil hydrochloride and nimodipine on cognitive impairment of vascular dementia（VaD）. Methods From February 2009 to June 2012,84 VaD patients were randomly divided into donepezil hydrochloride group（42 cases, donepezil hydroehloride orally）and nimodipine group（42 cases, nimodipine orally）. After 12 weeks of treatment,the degree of dementia was observed and compared between two groups. Results After treatment,MMSE scores were significantly different from before treatment in both groups（P〉0.05）. The MMSE score in donepezil hydrochloride group was significantly better than that in nimodipine group after treatment（P〈0.05）. The total effective rate in donepezil hydrochloride group was 95.2%, and which was 76.2% in nimodipine group. The total effective rate in donepezil hydrochloride group was significantly higher than that in nimodipine group（P〈0.05）. Conclusion Donepezil hydrochloride is better than nimodipine in the treatment of VD and can improve the degree of dementia of VD patients. It is safe,effective and worthy of clinical application.