对HP阳性的功能性消化不良患者行根除HP治疗的疗效分析

Analysis about the clinical effect of eradicating the HP for functional dyspepsia patients with HP-positive

目的:探索根除幽门螺杆菌(HP)对HP阳性的功能性消化不良(FD)患者的临床意义,为FD的临床治疗提供参考。方法:将80例确诊为FD且HP阳性的患者随机分为治疗组和对照组,分别接受改善FD症状+HP根除的综合治疗和改善FD症状的单一治疗。治疗4周后,评价临床治疗效果。结果:治疗组与对照组相比,治疗后上腹痛综合征(EPS)、餐后不适综合征(PDS)的积分数值差异无统计学意义(P>0.05)。治疗组中HP根除成功患者与失败患者相比,EPS、PDS积分值差异也无统计学意义(P>0.05)。所有患者经治疗后,其FD症状均有显著改善。结论:HP是否根除对FD症状的改善不具有直接的临床意义,在改善FD症状中起主导作用的是药物本身,而非根除HP。

Objective： To explore the clinical significance of eradicating the HP for HP-positive functional dyspepsia（FD） patients, and to provide a reference for the clinical treatment of FD. Methods： 80 patients diagnosed as FD and HP-positive were randomly divided into treatment and control groups and respectively received comprehensive treatment of FD ＋ HP eradication and mono-therapy to improve FD symptoms. After four weeks of treatment, clinical effects were evaluted. Results： There was no significant difference on the integral value of EPS and PDS（P 〉0.05） between treatment group and control group. There was no statistically significant difference in the value of EPS and PDS （ P 〉 0. 05 ） between patients with successful HP eradication and patients who failed to eradicate HP. FD symptoms have significantly improved in all patients. Conclusion ： Eradication of HP do not have direct clinical significance for improve FD symptoms, the drug play a leading role in improving FD symptoms, rather than the eradication of HP.