摘要
目的 探讨神经元特异度烯醇化酶（NSE）、癌胚抗原（CEA）、鳞状细胞癌抗原（SCCA）、细胞角蛋白19片段（CYFRA21-1）和胃泌素释放肽前体（ProGRP）在肺癌诊断中的价值,分析几项肿瘤标志物水平与其病理分型的关系.方法 采用化学发光法分别检测64例肺癌患者,58例肺良性疾病患者血清NSE,CEA,SCCA,CYFRA21-1及ProGRP的含量.结果 肺癌组各肿瘤标志物血清水平皆显著高于肺部良性疾病组（t=3.36～7.41,P值均〈0.05）,NSE＋CEA＋CYFRA21-1＋SCCA＋ProGRP 联检对肺癌诊断的灵敏度、特异度和准确度分别为81.25%,82.76%和81.97%,灵敏度和准确度明显大于各标志物单项检测（t=3.11～4.13,P值均〈0.05）,肺癌肿瘤标志物血清水平与病理类型有关,血清NSE,ProGRP水平在小细胞肺癌（SCLC）时显著升高（F=31.20,P〈0.05）,CEA在腺癌时显著升高（F=25.36,P〈0.05）,而血清CYFRA21-1和SCCA水平则在鳞癌时显著升高（F=11.24～25.36,P值均〈0.05）.结论 NSE,CEA,CYFRA21-1,SCCA及ProGRP肿瘤标志物检测有利于指导肺癌的病理分型,其联检明显提高了对肺癌诊断的灵敏度.
Objective To study the diagnostic value and pathological classfication of determination of serum levels of NSE, CEA,CYFRA21-1,SCCA and ProGRP inpatients with lung cancer. Methods Serum NSE, CEA, CYFRA21-1, SCCA and ProGRP （with CLIA） levels were measured singly or combinedly in 64 patients with lung cancer and 58 patients with vari-ous kinds of benign lung disorders. Results The levels of serum NSE,CEA,CYFRA21-1,SCCA and ProGRP in patients with lung cancer were all significantly higher than the respective levels in patients with benign lung diseases （P〈0.05）. The sensitivity and accuracy of combined determination of NSE, CEA, CYFRA21-1 was 81.25%, 82.76% and 81.97% respec-tively,being higher （P〈0. 05） than that with any single determination. For various pathological types of lung cancer,the levels of NSE and ProGRP in SCLC were significantly higher than adenocarcinom and squamous ceil carcinoma, the levels of CEA in adenocarcinom was significantly higher than SCLC,and the levels of CYFRA21-1 and SCCA in squamous cell earci-noma were significantly higher than adenocarcinom and SCLC. Conclusion Determination of serum levels of NSE,CEA,CY-FRA21-1 ,SCCA and ProGRP is helpful for clinical diagnosis of lung cancer,combined determination can increase the sensi-tivity.
出处
《现代检验医学杂志》
CAS
2013年第5期89-92,共4页
Journal of Modern Laboratory Medicine
