火热证与唾液理化指标的相关性研究

Correlation of Fire-heat Syndrome with Physiochemical Indexes of Saliva

【目的】研究火热证及其与唾液溶菌酶(LYZ)、唾液免疫球蛋白(SIgA)、唾液淀粉酶(AMS)及唾液流率(SFR)的相关性。【方法】从广州、湖南以及河南等3个地区收集病例,分别检测火热证及恢复健康后的唾液溶菌酶、唾液免疫球蛋白、唾液淀粉酶及唾液流率,采用自身对照分析火热证恢复健康前后各指标的变化,通过相关性检验探索火热证与各指标的相关性。【结果】SFR在火热证患者恢复健康前后比较差异无统计学意义(P>0.05),LYZ和SIgA在恢复健康后显著增加(P<0.01),AMS在恢复健康状态后显著降低(P<0.05)。经相关性检验:火热证诊断记分与SIgA呈显著负相关(r=-0.404,P=0.000),其余的检测指标与火热证诊断记分均无显著性相关。湖南地区与河南地区除了SIgA外,其余3个指标自身对照结果与广州地区呈现不一致趋势。但是3个地区结果显示火热证评分与SIgA具有显著相关(P=0.000)。【结论】通过对3个地区研究发现火热证与唾液SIgA呈显著负相关,SIgA可以作为评价火热证的一个参考指标。

Objective To investigate the correlation of fire-heat syndrome with physiochemical indexes of saliva such as salivary lysozyme （LYZ）, salivary immunoglobulin A （SIgA）, amylase of saliva （AMS） and salivary flow rate （SFR） . Methods Volunteers with fire-heat syndrome were collected from Guangzhou region, Hunan and Henan province. LYZ, SIgA, AMS and SFR were detected in fire-heat syndrome volunteers and then compared with those in the volunteers recovering to health. The correlation of fire-heat syndrome with physiochemical indexes of saliva such as LYZ, SIgA, AMS, and SFR was investigated. Results The results showed that there was no significant difference of SFR between volunteers being the fire-heat syndrome and volunteers recovering to health （P〉O.05）, but LYZ and SIgA were increased （P〈0.01） and AMS was decreased （P〈O.05） in the volunteers recovering to health. The results of correlation test showed that the diagnostic scores of fire-heat syndrome were negatively correlated with SIgA level （r =-0.404, P=0.000） , while were not correlated with the other physiochemical indexes. The results of verification test in Henan province and Hunan province showed that diagnostic scores of fire-heat syndrome were also negatively correlated with SIgA level （P=0.000）, but SFR, LYZ and AMS showed inconsistent trends with those in Guangzhou region, while results from all the areas showed that there were significant difference between scores and SIgA （P---0.000）. Conclusion The results of diagnostic scores of fire-heat syndrome being negatively correlated with SIgA level in the three regions indicated that SIgA could be expected as a reference index for the diagnosis of the fire-heat svndrome.