肺炎支原体的耐药机制及治疗

Summarized on Drug Resistance Mechanism and Treatment in Mycoplasma Pneumoniae Infection

肺炎支原体(MP)为常见的儿童呼吸道感染病原体之一。随着大环内酯类抗菌药物的广泛应用,耐大环内酯抗菌药物菌(MRMP)呈上升趋势,MRMP感染人群已向成年人蔓延。MRMP较敏感菌株导致感染个体的临床症状持续时间长,肺外并发症发病率高。笔者拟就肺炎支原体流行病学、耐药机制及MRMP的治疗,综述如下。

Mycoplasma pneumoniae is one of major pathogens in community acquired respiratory tract in children and adults. But with macrolides abused, the macrolide-resistance Mycoplasma pneumoniae （MRMP） were dramatically grown, and the MRMP infection spreaded from children to adults in recent years. Many studies demonstrated that the clinical symptoms of MRMP infection were longer and extrapulmonary complications incidence rate was higher than the sensitive strain infection. In this paper, epidemiology, mechanism of resistance and drug resistant strainrs treatment of Mycoplasma pneumoniae were summarized by review literatures.