西宁地区乙型肝炎表面标志物阳性模式的探讨及临床意义

Surface Markers of Hepatitis B and its Significance in HBV Patients in Xining

目的：对西宁地区慢性乙型肝炎血清标志物的模式进行统计,检测乙型肝炎病毒（HBV DNA）含量、前SI抗原（Pre-SIag）及肝功能,探讨其相关性及临床意义。方法：采用酶联免疫吸附试验（ELISA）检测3 540例西宁地区乙肝患者的HBV Pre-Siag、表面抗原（HBsAg）、表面抗体（抗HBs）、e抗原（HBeAg）、e抗体（抗HBs）、核心抗体（抗HBE）、定量聚合酶链反应（PCR）检测HBV DNA,日立2400全自动生化分析仪检测丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、γ-谷氨酰基转移酶（GGT）。结果：西宁地区乙型肝炎患者中（20-35）岁年龄组的青年占大多数（2 408例,68.02%）,Pre-Siag、HBsAg、HBeAg,抗HBe阳性率明显高于其他年龄组患者。结论：西宁地区乙型肝炎患者好发于中青年,这可能与他们的生活方式及饮食习惯有关。加强这个年龄段患者乙型肝炎的防治,控制患者肝功能的恶化是首要任务。

Objective：To deal with the distribution of surface markers of hepatitis B and its clinical significance in HBV patients in Xining area. Methods：A total of 3 540 cases of hepatitis B were collected from Jan 2010 to Jun 2012 in this study, of them,2 408 cases （68.02%） were 20 -35 year old youths. HBV Pre -SI and HBV mark ers were quantitatively measured by enzyme linked immune - sorbent assay （ELISA）. The serum level of HBV2 DNA was detected quantitatively by polymerase chain reaction （PCR）. The ALT,AST and GGT level was measured using HITACHI 7600 automatic biochemistry analyzer. Results： In 70.27% of 2 408 young patients with HBV, lev el of Pre - Siag, HbsAg, HbeAg and HbeAb were significant higher than those in other cases. Conclusions： HBV was infected easily in young and middle - aged persons in Xining, this may be related to the mode of their lifestyle and eating habits, so work of strengthen prevention and treatment of hepatitis B type in youngers were importance in future.