放射性核素骨显像在可注射性骨修复材料治疗犬股骨颈骨折实验中的应用价值

Experimental study of repairing canine femoral neck fracture by injectable osteoinductive material and the application of radionuclide imaging

目的探讨可注射性骨修复材料在犬股骨颈骨折中的修复能力及放射性核素骨显像技术在此过程中的应用价值。方法健康成年杂种犬12只,每只犬左右两侧股骨头、颈分别作为对照侧与实验侧。实验侧应用中空加压螺钉复合可注射骨形态发生蛋白(BMP)缓释载体,对照侧单纯植入中空加压螺钉,术后4、8、12周分别通过放射性核素骨显像进行监测。结果放射性核素骨显像中感兴趣区(ROI)计数和摄取比值显示实验组随着时间的延长再血管化的数量和成骨的质量呈现出上升的趋势。结论可注射性骨修复材料具有良好的修复犬股骨颈骨折的能力,放射性核素骨显像在修复过程中有非常准确的预测效果。

Objective To study the values of repairing canine femoral neck fracture by injectable osteoinductive material monitored by ra dionuclide imaging. Methods Bone imaging was used to monitor the distribution of radioactivity in the fracture at 4, 8, 12 weeks after operation. Results 99mTC - MDP uptakes and ratios of the region of interesting （ROI） indicated that there had a rising tendency in experiment group. Conclusion Injectable Osteoinductive Material has good ability to repair femoral neck fracture, 99mTC - MDP ECT is a effective method to moni- tor the repairing process.