结肠癌根治术后肝转移的相关因素分析

Study on risk factors for liver metastasis after radical resection of colon cancer

目的探讨结肠癌根治术后肝转移的相关因素。方法回顾性分析306例结肠癌根治术患者的临床病理资料及术后随访情况。结果 306例患者中72例发生肝转移,发生率为23.5%。单因素分析显示,患者年龄、肿瘤分化程度、大体类型、脉管侵犯、淋巴结转移、清扫淋巴结数、术前CEA水平、手术时间均影响肝转移(P<0.05)。logistic回归分析显示,肿瘤分化程度、脉管侵犯及淋巴结转移是肝转移的独立危险因素(P<0.05)。结论肿瘤分化不良、有脉管侵犯及淋巴结转移的结肠癌根治术后肝转移的风险增大。

Objective To explore the risk factors for liver metastasis after radical resection of colon cancer. Methods The clinical patho logical data and situation of postoperative follow up of 306 patients with colon cancer were retrospectively analyzed. Results The incidence of liver metastasis from colon cancer was 23.5 % （72/306）. Univariate analysis showed that age, histological differentiation, gross type, vascular in vasion, lymph node metastasis, number of lymph nodes dissected, preoperative serum level of CEA and operating time were relevant to liver metas tasis （ P 〈 0.05 ）. Logistic regression analysis showed that histological differentiation, vascular invasion and lymph node metastasis were correlated with liver metastasis （ P 〈 0.05 ）. Conclusion Patients with poorly differentiated colon canceer, vascular invasion or lymph node metastasis have higher chance of liver metastasis after radical resection of colon cancer.