妊娠期高血压疾病与胎盘生长因子的相关性及意义

Study on significance and relationship between serum level of placental growth factor and hypertensive disorders of pregnancy

目的检测妊娠期高血压疾病(HDCP)患者血清胎盘生长因子(PLGF)含量水平,探讨HDCP与PLGF的相关性及意义。方法随机选择HDCP患者60例为病例组,并选择同期住院的正常孕妇60例为对照组,采用酶联免疫吸附(ELISA)法测定妊娠的不同时期孕妇血清PLGF的含量水平。结果 HDCP患者血清PLGF水平均明显低于相同孕期对照组(P<0.05),并且随着HDCP病情加重血清PLGF水平呈下降趋势。结论血清PLGF与HDCP的发生发展密切相关,血清PLGF含量的下降可以作为HDCP诊断的一项有效的临床指标。

Objective To detect the change in serum level of placental growth factor （PLGF） during different periods of pregnancy and the change in expression of serum PLGF in patients with hypertensive disorders of pregnancy group and control group, in order to explore the corre lation and significance of PLGF in patients with hypertensive disorders of pregnancy. Methods Enzyme linked immunosorbent assay （ELISA） had been applied to detect the expression levels of serum PLGF in patients with hypertensive disorders of pregnancy group and control group. Re stilts The serum level of PLGF in patients with hypertensive disorders of pregnancy was significantly lower than that of control group（ P 〈 0.05 ）. The level of serum PLGF was decreased following the deterioration of condition of hypertensive disorders of pregnancy. Conclusion The decrease in serum level of PLGF may be used as an effective clinical indicator for prediction of hypertensive disorders of pregnancy.