上皮钙粘附素及相关蛋白连接素在胃癌中的表达及其临床意义

Expression of E-cadherin and its Associated Protein α and β-catenin and Their Signification in Human Gastric Carcinoma

目的 探讨上皮钙粘附素 (E cd)及其相关蛋白连接素 (catenin)在胃癌中的表达及其意义。方法 应用免疫组织化学S P法检测E cd及catenin在 6 0例胃癌中的表达。结果 在各型胃癌中 ,E cd/catenin复合物 1项以上的成分表达异常高达83 .3 % (5 0 /6 0 )。E cd、α catenin表达与胃癌的浸润深度、Lauren′s分型密切相关 (P <0 .0 1) ,与淋巴结转移无关 (P >0 .0 5 ) ;而 β catenin表达与胃癌的浸润深度和Lauren′s分型无关 (P >0 .0 5 ) ,但与淋巴结转移有关 (P <0 .0 5 ) ;E cd、β catenin表达阳性者 3年生存率明显好于阴性表达者。结论 E cd/catenin复合物染色异常在胃癌中极其常见 ,它们与胃癌的临床病理学不同特征密切相关 ,可作为评价胃癌生物学特性的较好指标。

Objective To investigate E-cadherin and its associated protein α-catenin and β-catenin expression and their significances in gastric carcinoma.Methods Immunohistochemical S-P method was used in 60 cases of gastric carcinoma for detection of E-cadherin and catenin.Results Up to 83.5%(50/60) of the gastric carcinomas were stained abnormally with one or more components of the E-cadherin/catenin complex.The abnormal expression of E-cadherin and α-catenin,but not β-catenin were correlated with the depth of cancer invasion and Lauren′s classfication in gastric carcinoma(P<0.01),there was no relation between lymph rode metastasis and their expression(P>0.05),whereas the abnormal expression of β-catenin was related with lymph rode metastasis(P<0.05).The patients with normal expression of E-cadherin and β- catenin had a far more better surveval than those negative cases.Conclusion Abnormal expression of E-cadherin and its associated protein catenins occur frequently in gastric carcinoma.The correlation with different clinicopathologic feature suggests that E-cadherin,α-catenin and β- catenin may be useful markers for assessing biological characteristics of gastric cancer.