浙江省2010-2012年麻疹成分疫苗疑似预防接种异常反应监测分析

Monitoring analysis of adverse events following immunization of measles contained vaccine in Zhejiang from 2010 to 2012

目的 评价含麻疹成分疫苗（MCV）预防接种的安全性.方法 通过全国疑似预防接种异常反应（AEFI）监测系统和中国免疫规划监测信息管理系统,收集浙江省2010-2012年报告的MCV AEFI个案数据及接种数据,采用描述性流行病学方法进行分析.结果 2010-2012年,AEFI监测系统共报告接种MCV AEFI个案1549例,报告发生率210.85/100万剂；一般反应报告发生率143.74/100万剂,异常反应报告发生率56.63/100万剂；严重异常反应发生率极低.麻疹-流行性腮腺炎联合减毒疫苗（MMV）强化免疫AEFI报告发生率为367.08/100万剂,明显高于MCV常规免疫报告发生率（134.02/100万剂,Z=20.00,P＜0.01）.AEFI个案中,男女性别比为1.61∶1,3岁以内儿童为主,发生时间主要集中在接种后1d内.结论 MCVAEFI报告发生率在预期范围内,以一般反应为主.总体而言,MCV安全性良好.

Objective To evaluate the immunization safety of the measles contained vaccine （MCV）.Methods The data of MCV adverse events following immunization （AEFI） and the vaccination data were collected through the AEFI surveillance system and China immunization monitoring information management system from 2010 to 2012.The descriptive epidemiology method was used in the study.Results From 2010 to 2012,1549 AEFI cases of MCV were reported in the surveillance system and the incidence of AEFI of MCV was 210.85 per million doses among which the common vaccine reaction incidence was 143.74 per million doses.The rare vaccine reaction incidence was 56.63 per million doses and the serious rare vaccine reaction incidence was very low.The incidence of AEFI was higher during measles and mumps combined attenuated live vaccine （MMV） booster immunization than that during routine immunization （367.08 per million doses and 134.02 per million doses,Z=20.00,P〈0.01）.The sex ratio of male and female was 1.61∶1,most of the cases were younger than 3 years old.The vaccine reactions were mainly happened one day after vaccination.Conclusions AEFI of MCV reactions incidence is in expected range,and the main vaccine reactions are common.Overall,MCV has good safety.