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适用于荧光成像的化学发色团与生物正交反应研究进展 被引量：4

Recent progress on the development of probes for fluorescent imaging and bio-orthogonal reactions
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摘要 荧光成像是一种融合多门现代学科的显像方法,其运用荧光成像探针实现对细胞及动物体内的生物大分子的动态、可视化观察,为疾病的诊断与治疗提供了有力的方法.理想的荧光发色团和细胞环境友好的生物正交反应是构建性能优良的活细胞荧光成像探针的两大因素,本综述总结了近年来在荧光发色团及生物正交反应方面最新的研究进展. Fluorescent imaging is a multidisciplinary integrated technology for bio-imaging. Application of fluorescent probes allows dynamic visualization of large bio-molecules inside cells and animals, which can benefit the diagnosis and treatment of various diseases. Satisfactory fluorophores and bio-orthogonal reactions play crucial roles in the construction of ideal fluorescent probes for in vivo imaging of cellular biopolymers and biological events. This review summarized the recent advance in these two areas with examples illustrating the applications in fluorescent bio-imaging.
作者 张艳 陈鹏 姚祝军
机构地区 南京大学化学化工学院 北京大学化学与分子工程学院
出处 《科学通报》 EI CAS CSCD 北大核心 2013年第28期2872-2885,共14页 Chinese Science Bulletin
基金 国家重点基础研究发展计划(2010CB833202) 国家自然科学基金(91213303)资助
关键词 荧光成像 生物大分子 荧光发色团 生物正交反应 定量生物学 fluorescent imaging, biopolymer, fluorophore, bio.orthogonal reaction, quantitative biology
分类号 O644.1 [理学—物理化学]
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同被引文献68

  • 1胡华军,付涛,张明洲,洪治,陈宗伦,刘军.CdTe/ZnSe核壳量子点免疫层析试纸条检测克伦特罗的研究[J].分析化学,2010,38(12):1727-173l. 被引量：32
  • 2陈伟,沈鹤柏,陈艳,周丽佳,徐文涛.新型荧光物质——量子点在生命科学领域的应用研究进展[J].化学通报,2007,70(6):403-408. 被引量：10
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  • 5YAMAZAKI W, ISHIBASHI M, KAWAHARA R, et al. Development of a loop-mediated isothermal amplification assay for sensitive and rapid detection of Vibrio parahaemolyticus[J]. BMC Microbiology, 2008, 8(1): 163.
  • 6CHEN S, GE B. Development of a toxR.-based loop- mediated isothermal amplification assay for detecting gibrio parahaemolyticus[J]. BMC Microbiology, 2010, 10(1): 41.
  • 7HARA-KUDO Y, NISHINA T, NAKAGAWA H, et al. Improved method for detection of Vibrio parahaemolyticus in seafood[J]. Applied and Environmental Microbiology, 2001, 67(12): 5819-5823.
  • 8NORDSTROM JL, VICKERY MC, BLACKSTONE GM, et al. Development of a multiplex real-time PCR. assay with an internal amplification control for the detection of total and pathogenic Vibrio parahaemolyticus bacteria in oysters [J]. Applied and Environmental Microbiology, 2007, 73(18): 5840-5847.
  • 9BLACKSTONE GM, NORDSTROM JL, VICKERY MC, et al. Detection of pathogenic lbrio parahaemolyticus in oyster enrichments by real time PCR.[J]. Journal of Microbiological Methods, 2003, 53 (2): 149 - 155.
  • 10WARD LN, BEJ AK. Detection of lbrio parahaemolyticus in shellfish by use of multiplexed real-time PCR. with TaqMan fluorescent probes[J]. Applied and Environmental Microbiology, 2006, 72(3): 2031-2042.

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科学通报
2013年 第28期

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