肾炎3号方对离体肾小球培养系膜细胞增殖及IL-1水平的影响

The Effects of Shenyan No.3 on the Multiplication of Isolated Mesangial Cells and Their IL-1 Level

用不同药物喂家兔后取血清加入系膜细胞培养液中观察其增殖及产生IL 1的水平。结果 :肾炎 3号方可显著抑制正常及病理状态下肾小球系膜细胞增殖及其产生IL 1的水平 ,且抑制IL 1分泌活性强于雷公藤 (P <0 0 5)。提示肾炎 3号方可抑制肾小球系膜细胞增殖及其产生IL 1水平 ,打破以系膜细胞为中心的调节网络 。

In this experiment, different drugs including Shenyan No.3 (S No.3) were given to the rabbit first, and then the rabbit's serum was separated and added to into the mesangial cell culture solution; afterwards, an observation on mesangial cell multiplication and mesangial cell IL 1 level was made. The results showed that S No.3 could strikingly inhibit mesangial cell multiplication and mesangial cell IL 1 secretion under both normal and pathological conditions ( P <0 01), and the inhibiting effect of S No. 3 on mesangial cell IL 1 secretion was stronger than that of Tripterygium wilfordii ( P <0 05). The reults implies that S No.3 may have a good effect on the chronic nephritis with mesangial cell proliferation as a main evidence in its pathology.