血尿酸及尿微量白蛋白水平与原发性高血压颈动脉粥样硬化斑块形成的相关性

Correlation between serum uric acid and urinary albumin in patients with primary hypertension who had carotid arterial atherosclerotic plaque formation

目的：总结原发性高血压患者中血尿酸以及尿微量白蛋白水平与动脉硬化粥样斑块之间的相关性关系。方法：选取2009年5月～2012年11月期间我中心就诊的200例高血压患者为研究对象，分别进行血尿酸、尿微量白蛋白和双侧颈总动脉内膜检测，按照血尿酸以及尿微量白蛋白检测结果分成A组（血尿酸组）52例、B组（尿微量白蛋白组）49例、c组（正常组）49例、D组（混合组）50例，分析比较4组患者颈动脉粥样硬化斑块形成的发生率。结果：A组、B组和D组内膜增厚和硬化斑块的发生率明显高于C组，且差异显著（P〈0．05）；D组内膜增厚和硬化斑块的发生率明显高于A组、B组，且差异显著（P〈0．05）；A组、B组内膜增厚和硬化斑块的发生率差异无显著（P〉0．05）。结论：高血压患者的颈动脉内膜变化和血尿酸、尿微量白蛋白的水平呈正相关关系，所以，血尿酸和尿微量白蛋白可用于动脉粥样硬化的早期诊断指标，临床治疗中在降血压的同时要注意血尿酸和尿微量白蛋白的有效控制。

Objective：To investigate the correlation between serum uric acid and urinary albumin in patients with primary hypertension who had carotid arterial atherosclerotic plaque formation. Methods： We recruited 200 consecutive patients with hypertension from Xiluoyuan Community Health Center between May 2009 and November 2012 who were subsequently subjected to measurement of uric acid, urine microalbumin and bilateral carotid artery intimal diameter. This allowed subject allocation to group A（ blood uric acid group, n = 52 ） , group B （ urinary albumin group, n = 49 ）, group C （ normal group, n = 49 ） and group D （ mixed group, n = 50 ） based on the levels of blood uric acid and urine microalbumiu. The incidence of carotid arterial atherosclerosis plaque formation was compared. Results： Compared with group C,groups A,B and D evidenced impressive intimal thickening and significantly higher incidence of plaque formation （ all P 〈 0.05 ）. Furthermore, group D had a marked intimal thickening and an increased incidence of plaque formation compared with groups A and B （ both P 〈 0.05 ）. However,the difference in intimal thickness and incidence of plaque formation between group A and B was unremarkable（P 〉 0.05 ）. Conclusion： In patients with hypertension, changes in carotid intimal thickness are positively correlated with the levels of blood uric acid and urine albumin, which may be regarded as worthwhile for early diagnosis. Effective control of serum uric acid and urinary albumin is warranted for anti-hypertensive therapy in clinical practice.