血醛固酮和纤维蛋白原在原发性高血压患者左心室肥厚中的作用

Effects of blood aldosterone and fibrinogen on left ventricular hypertrophy in essential hypertension

目的:探讨血醛固酮和纤维蛋白原在原发性高血压患者左心室肥厚中的作用。方法:收集2011年9月至2012年12月收治的205例原发性高血压患者作为研究对象,观察年龄、LVMI、LVEF、E/A比值、DT等指标与纤维蛋白原水平的相关性。结果:LVMI与不同的纤维蛋白原水平具有显著相关性(P<0.05),而LVEF和舒张功能(E/A比值和DT)与血纤维蛋白原水平无关(P>0.05)。与正常LVMI的患者相比,LVMI升高的患者年龄更大、收缩压更高、血清醛固酮和血清纤维蛋白原水平均升高(P<0.05)。LVMI与患者年龄、收缩压、体质量指数、纤维蛋白原水平和醛固酮水平独立相关(P<0.05)。结论:原发性高血压患者醛固酮和纤维蛋白原水平增加,且与LVMI相关。

Objective： To determine the effects of blood aldosterone and fibrinogen on left ventricular hypertrophy in essential hypertension. Methods： We recruited 205 patients with essential hypertension between September 2011 and December 2012. This entailed subsequent analysis on the correlation between fibrinogen and the age, LVMI, LVEF, E/A ratio and DT. Results ： LVMI correlated significantly with blood fibrinogen （ P 〈 0. 05 ） , but not LVEF nor diastolic capacity （ E/A ratio or DT） （ all P 〉 0.05 ）. Compared with patients with normal level of LVMI, those with elevated LVMI had an increased age, higher systolic blood pressure, serum aldosterone and fibrinogen （ all P 〈 0.05 ）. LVMI was independently eorrelated with the age, systolic blood pressure, body-mass index and serum aldosterone （ all P 〈 0. 05 ）. Conclusion： Patients with essential hypertension had an elevated level of a]dosterone and fibrinogen that were correlated with LVMI.