脑脊液置换合并尼莫地平静脉滴注在非手术治疗急性硬膜下血肿中的应用

Cerebrospinal fluid replacement and intravenous nimodipine as a non-surgical treatment for acute subdural hematoma

目的:探讨和评价急性硬膜下血肿脑脊液置换合并尼莫地平静脉滴注非手术救治模式。方法:回顾性分析了采用脑脊液置换合并尼莫地平静脉滴注治疗模式的急性硬膜下血肿患者76例,以采用一般保守治疗的83例急性硬膜下血肿患者为对照组,通过统计分析头痛缓解时间、并发症发生率及平均住院天数,评价脑脊液置换合并尼莫地平静脉滴注治疗模式的有效性。结果:脑脊液置换合并尼莫地平静脉滴注治疗组患者的并发症发生率显著低于对照组(P<0.05);头痛缓解时间及平均住院时间均显著少于对照组(P<0.05)。结论:脑脊液置换合并尼莫地平静脉滴注用于非手术治疗急性硬膜下血肿,优于常规内科保守治疗。

Objective： To study the effects of cerebrospinal fluid replacement in combination with intravenous nimodipine as a remedy therapy for acute subdural hematoma （ASH）. Methods： We did a retrospective analysis on the profiles of 76 patients with ASH who were treated with cerebrospinal fluid replacement and intravenous nimodipine. 83 patients with ASH treated with conventional treatment were allocated to control group. The efficacy was assessed based on the time to amelioration of headache, the incidence of complications and length of hospital stay. Results： The treatment group yielded a significantly lower incidence of complications and reduced time to amelioration of headache and length of hospital stay than control group（ all P 〈 0.05 ）. Conclusion： The treatment with cerebrospinal fluid replacement and intravenous nimodipine is superior to conventional medical treatment as a non-surgical therapeutic approach for ASH.