清肝利湿汤治疗肝胆湿热证的临床研究

Effects of Qingganlishi Decoction on Chronic Cholecystitis and Cholelithiasis with Wetness-Heat Syndrome of Liver and Gallbladder

为了探讨清肝利湿汤治疗肝胆湿热证的临床疗效 ,根据以证为主、证病结合的原则 ,选取慢性胆囊炎胆石症中属肝胆湿热证者 6 0例 ,随机分为清肝利湿汤治疗组 30例 ,胆石通胶囊对照组 30例 ;实验指标另设健康人对照组 30例。结果 :清肝利湿汤组总显效率为 6 3 .3% ,胆石通胶囊组为 36 .7% ,两组比较P <0 .0 5 ;实验研究结果 :肝胆湿热证患者血浆肿瘤坏死因子 (TNF α)、β 内啡呔 (β EP)、血清丙二醛 (MDA)均增高 ,血清超氧化歧化酶(SOD)下降 ,与健康人组比较P <0 .0 1,经清肝利湿汤治疗后血浆TNF α、β EP、血清MDA均下降、血清SOD上升 ,与治前比较P <0 .0 1。表明清肝利湿汤具有抗炎、镇痛、抗氧自由基损伤的作用。

To explore the effect of Qingganlishi decoction (QGLSD) in treating chronic cholecystitis and cholelithiasis with wetness-heat syndrome of liver and gallbladder. 60 patients were randomly devided into two groups. 30 patients were treasted with QGLSD and 30 patients with Danshitong capsule. Another 30 healthy persons was as the control group.Results:In 30 patients trested with QGLSD,the total marked effective rate was 63.3%. In 30 patients treated with Danshitong capsule. The total marked effective rate of QGLSD group was significantly higher than that of Danshitong capsule group(P<0.05).QGLSD has effect on treating chronic cholecystitis and cholelithiasis with wetness-heat syndrome of liver and gallbladder. It's mechanisms might be related to antibiotic、 analgesia、 anti-infammatory and anti-oxygen-free-radicals.