高效孕激素治疗子宫内膜不典型增生及早期内膜癌的疗效观察

To observe the curative effective of high progesterone on atypical endometrial hyperplasia and primary endometrial cancer

目的探讨高效孕激素在治疗子宫内膜不典型增生及早期内膜癌的临床效果。方法对43例年龄23~47岁,中位年龄31.7岁,诊刮病理诊断为子宫内膜不典型增生患者,17例年龄28~61岁,中位年龄38.9岁,诊断为子宫内膜腺癌患者,采用高效孕激素治疗并对其治疗效果进行比较。结果接受高效孕激素治疗后,子宫内膜不典型增生组治疗总有效率为95.3%;早期子宫内膜癌组治疗总有效率为70.6%;两组差异有统计学意义（P〈0.05）。对孕激素治疗无效行手术治疗的病变组织行病理学检查最终确诊为子宫内膜早期浸润癌。结论高效孕激素对子宫内膜不典型增生及早期子宫内膜腺癌具有显著疗效,值得临床推广。

Objective To explore the effective of high progesterone on atypical endometrial hyperplasia and primary endometrial cancer.Methods Choosed 43 patients during 23 to 47 years old, median age was 31.7, suffered with endometrial atypical hyperplasia, 17 with endometrial adenocarcinoma during 28 to 61 years old, with a median age was 38.9, both of which diagnosed by Curettage pathological diagnosis, comparing the effective being therapy by high progesterone.Results After accepted with high progesterone treatment, Total effective rate of atypical hyperplasia of endometrium group was 95.3%; total effective rate of primary endometrial cancer group was 70.6%; The two group had significant difference（P〈0.05）. While progestin therapy invalid for surgical treatment of diseased tissue for pathological examination finally diagnosed as early endometrial carcinoma.Conclusion High progesterone has significant effect on endometrial atypical hyperplasia and primary endometrial adenocarcinoma, worthy of clinical application.