体液中S-100蛋白与惊厥脑损伤及预后的关系

S-100 protein in bady fluids and seizures brain injury with prognosis

目的探讨不同原因的惊厥患儿血清及CSF中S-100的变化及常用神经保护剂干预后的变化规律。方法采用放射免疫分析法,测定71例惊厥患儿-2 d、-4 d、-7 d的血清S-100含量,18例惊厥患儿-2 d、-7 d CSF中S-100含量。结果①惊厥患儿血清S-100在发生惊厥后2 d内达高峰,多数-7 d达正常,以HIE及急性脑损伤增高最明显,其次为癫痫、其他原因（感染等）,高热惊厥中虽有增高趋势,但差异无统计学意义。②惊厥患儿CSF中S-100在-2 d内明显升高,-7 d时,已基本恢复正常。③血液及CSF中的S-100与后遗症的预后有关,以-2 d时的变化最明显。结论血清及CSF中S-100蛋白浓度不仅与脑损伤的程度有关,还可较准确地反映患儿的远期预后。

Objective Discuss the different reasons of seizures in serum and CSF children S- 100 change and commonly used neural protective agent after intervention the change rule.Methods using radiation immunoassay, were measured in 71 cases of children with convulsion - 2 day, - 4 days, -7 days of serum S- 100content, and 18 cases of children with convulsion - 2 day, - 7 days in CSF S- 100 content.Results 1. Children with convulsion serum S- 100 in case of convulsion within 2 days of peak, most - 7 days to normal, with HIE and acute brain injury heighten the most obvious, followed by epilepsy, other reasons（infection）, although there are higher in febrile convulsion trend, but no significant meaning. 2. Children convulsion in CSF S-100-2 days increased obviously, -7 days, has basically returned to normal. 3. Blood and CSF of S-100 and the prognosis of complications related to - 2 days the most obvious changes.Conclusion Serum and CSF of S-100 protein concentration and the degree of brain injury not only about, still can accurately reflect the long-term prognosis of patients.