期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

人呼吸道合胞病毒及其疫苗研究进展 被引量：1

Human respiratory syncytial virus and its vaccine development
原文传递
导出
摘要 人呼吸道合胞病毒（respiratory syncytial virus,RSV）是引起婴幼儿支气管炎和肺炎的主要病原体.虽然已经过半个多世纪的研究,但至今仍没有安全有效的RSV疫苗上市.科研人员经过几十年的努力,对RSV的分子生物学、流行病学、致病机制等方面的研究已取得重大进展.此文就RSV的病毒学特征、流行病学和疫苗研发策略做一综述. Human respiratory syncytial virus （RSV） is an important pathogen responsible for bronchitis and pneumonia in young children.No safe and effective vaccines are available so far.Great progress has been made in molecular biology,epidemiology,and pathogenic mechanism of RSV during the past several decades.In this paper,virological and epidemiological characteristics,and vaccine development strategies of RSV are reviewed.
作者 胡兵(综述) 方志正(综述)
机构地区 武汉生物制品研究所有限责任公司病毒疫苗研究室
出处 《国际生物制品学杂志》 CAS 2013年第5期248-252,共5页 International Journal of Biologicals
关键词 呼吸道合胞病毒 人 呼吸道合胞病毒疫苗 流行病学 Respiratory syncytial virus,human Respiratory syncytial virus vaccines Epidemiology
分类号 R392.7 [医药卫生—免疫学]
  • 相关文献

参考文献33

  • 1Chrobak E, Machura E, Wrzask M, et al. RSV infection course in infants and young children during hospitalization [J]. Przegl Lek, 2011, 68( 1 ) :63-67.
  • 2Lantto M, Renko M, Uhari M. Changes in infectious disease mortality in children during the past three decades [ J ]. Pediatr Infect Dis, 2013, 3(27) :22-26.
  • 3Walsh EE, Peterson DR, Kalkanoglu AE, et al. Viral shedding and immune responses to respiratory syncytial virus infection in older adults [J]. Infect Dis,2013,207(9) :1424-1432.
  • 4van Drunen Littel-van den Hurk S, Watkiss ER. Pathogenesis of respiratory syncytial virus [ J ]. Curt Opin Virol, 2012, 2 (3) : 300-305.
  • 5Tran TL, Castagne N, Dubosclard V, et al. The respiratory syncytial virus M2-1 protein forms tetramers and interacts with RNA and P in a competitive manner [J]. J Virol, 2009, 83(13): 6363- 6374.
  • 6Spann KM, Tran KC, Chi B, et al, Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [J]. J Virol, 2004, 78 (8) :4363-4369.
  • 7Zhang ZY, Du LN, Chen X, et al. Genetic variability of respiratory syncytial viruses (RSV) prevalent in Southwestern China from 2006 to 2009 : emergence of subgroup B and A RSV as dominant strains [ J ]. J Clin Microbiol, 2010, 48 (4) : 1201-1207.
  • 8Rebuffo-Scheer C, Bose M,He J,et al. Whole genome sequencing and evolutionary analysis of human respiratory syncytial virus A and B from Milwaukee, WI 1998-2010 [J]. PLoS One, 2011, 6(10) : e25468.
  • 9Ohno A, Suzuki A, Lupisan S, et al. Genetic characterization of human respiratory syncytial virus detected in hospitalized children in the Philippines from 2008 to 2012 [J]. J Clin Virol, 2013, 57( 1 ) :59-65.
  • 10Qin X, Zhang C, Zhao Y, et al. Genetic variability of subgroup A and B respiratory syncytial virus strains circulating in southwestern China from 2009 to 2011 [J]. Arch Virol, 2013,2(27) :40-46.

二级参考文献11

共引文献1

同被引文献2

引证文献1

二级引证文献2

国际生物制品学杂志
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部