摘要
在真核生物的染色质结构中,核小体核心组蛋白氨基末端可以被组蛋白乙酰基转移酶(HATs)和去乙酰基酶(HDACs)修饰。这种可逆乙酰化修饰作用可使染色质结构发生动态调整,从而影响基因的转录活性。
参考文献1
-
1C. A. Mizzen,C. D. Allis. Linking histone acetylation to transcriptional regulation[J] 1998,Cellular and Molecular Life Sciences(1):6～20
同被引文献25
-
1Zhu B, Don Benjamin, Yong Zheng, et al. Overexpression of 5-methylcytosine DNA glycosylase in human embryonic kidney cells EcR293 demethylates the promoter of a hormone-regulated reporter gene. Cell biology, 2001,98(9):5031-5036.
-
2Bellier S, Chastant S, Adenot P. Nuclear translocation and carboxylterminal domain phosphorylation of RNA polymerase Ⅱ delineate the two phases of zygotic gene activation in mammalian embryos.EMBO, 1997,16(20):6250-6226.
-
3Li E. Chromati n modification and epigenetic reprogramming in mammalian development. Nat Rev Genet, 2002,3(9):662-673.
-
4Reik W, Constancia M, Fowden A, et al. Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.Physiol, 2003, 547(1):35-44.
-
5Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science, 2001,293(5532):1089-1093.
-
6Wutz A, Smrzka OW, Schweifer N, et al. Imprinted expression of the Igf2r gene depends on an intronic CpG island. Nature, 1997,389(6652):745-749.
-
7De Rycke M, Liebaers I, Van Steirteghem A. Epigenetic risks related to assisted reproductive technologies: risk analysis and epigenetic inheritance. Hum Reprod, 2002,17(10):2487-2494.
-
8Wolffe AP, Dimitrov S. Histone-modulated gene activity: developmental implications. Crit Rev Eukaryot Gene Expr, 1993,3(3):167-191.
-
9Rougier N, Bourc'his D, Gomes DM, et al. Chromosome methylation patterns during mammalian preimplantation development. GenesDev, 1998,12(14):2108-2113.
-
10Stein P, Worrad DM, Belyaev ND, et al. Stage-dependent redistributions of acetylated histones in nuclei of the early preimplantation mouse embryo. Mol Reprod Dev, 1997,47(4):421-429.
-
1吕建祎,张业,沈珝琲.稳定表达SirT7对其转染的P19细胞的增殖抑制作用[J].中国医学科学院学报,2009,31(6):724-727. 被引量：1
-
2董亚茹,杜建勋,陈传杰,赵东晓,王照红.组蛋白去乙酰化酶(HDACs)及其在植物中的作用[J].生物技术通报,2016,32(9):44-49. 被引量：5
-
3Shen Yufei (National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical Sciences Beijing 100005,China).染色质动态调整与基因转录[J].生物工程进展,1999,19(4):23-27. 被引量：2
-
4葛少钦,段斐,康现江,赵梦然.精子发生过程中组蛋白H4乙酰化修饰[J].生命的化学,2009,29(2):272-274. 被引量：1
-
5夏德安,刘春娟,吕世博,张彦妮,刘奕佳,马旭俊.植物组蛋白乙酰基转移酶的研究进展[J].生物技术通报,2015,31(7):18-25. 被引量：7
-
6熊光华,潘杰,马宗源.昆虫组蛋白去乙酰化酶HDACs的研究进展[J].应用昆虫学报,2012,49(3):770-777.
-
7李永强,张东.牛卵母细胞减数分裂期组蛋白H4K12乙酰化的变化[J].畜牧与饲料科学,2010,31(2):148-150. 被引量：2
-
8舒广文,宋建国.组蛋白去乙酰化酶抑制剂诱导肿瘤细胞凋亡的分子机制[J].生命的化学,2011,31(6):765-771. 被引量：2
-
9Guest editors Yi Zhang.Recent progress in the epigenetics and chromatin field[J].Cell Research,2011,21(3):373-374. 被引量：3
-
10曹佳,丁丽华,范忠义,程龙,蒋凯,徐晓洁,韩永健,徐承水,叶棋浓.核心组蛋白的融合表达和纯化[J].生物技术通讯,2011,22(4):484-487.
