原发性肝癌合并门静脉癌栓的治疗进展

Recent advances in the treatment of hepatocellular carcinoma with portal vein tumor thrombus

近年来,随着以肝功能损害程度、肿瘤直径大小和其他相关因素为背景的肝癌各种治疗方法出现,治疗效果评价也逐渐转向以循证医学的模式。目前临床对于肝癌合并门静脉癌栓的治疗方法较多,然而单一治疗方法效果较差,中位生存期较低,合理的治疗原则一直尚未建立。本文通过综述肝癌合并门静脉癌栓的最新治疗进展,以便为临床治疗提供有效参考。

Traditionally, the clinical therapeutic scheme for hepatocellular carcinoma associated with portal vein tumor thrombus has been based on the degree of liver function damage, the size of tumor and other relevant factors. Recently, the therapeutic design has tuned to the evidence- based model. There are many therapeutic means to deal with hepatoeellular carcinoma complicated by portal vein tumor thrombus. However, the use of single therapeutic means has poor curative effect and shorter median survival time. In addition, a reasonable therapeutic principle has not established yet. This paper aims to make a comprehensive review conceming the recent advances in the treatment of hepatocellular carcinoma with portal vein tumor thrombus in order to provide useful reference for clinical practice.