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糖尿病心肌缺血再灌注损伤的研究进展 被引量:1

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摘要 近年来,糖尿病发病率呈直线上升趋势,其作为缺血性心脏病(IHD)的主要危险因素之一也越来越引起人们的重视。研究表明,合并有糖尿病的IHD患者诱发心肌缺血再灌注损伤的几率是非糖尿病IHD患者的2~3倍,糖尿病的诸多合并症都会增加心脏对IHD的敏感性,因此糖尿病心肌缺血再灌注损伤及保护的研究逐渐受到关注。寻找有效的糖尿病心肌缺血再灌注保护方法,探寻其机制已成为当今研究热点。
出处 《中华胸心血管外科杂志》 CSCD 北大核心 2013年第10期637-640,共4页 Chinese Journal of Thoracic and Cardiovascular Surgery
基金 国家自然科学基金(81100137)
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  • 1Preis SR, Pencina M J, Hwang S J, et al. Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study. Circulation,2009,120:212-220.
  • 2Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics-2011 update: a report from the American Heart Associa- tion. Circulation, 2011,123 :e18-e209.
  • 3Donahoe SM, Stewart GC, McCabe CH, et al. Diabetes and mortali- ty following acute coronary syndromes. JAMA ,2007,298:765-775.
  • 4Franco OH, Steyerberg EW, Hu FB, et al. Associations of diabetes mellitus with total life expectancy and life expectancy with and with- out cardiovascular disease. Arch Intern Med,2007,167 : 1145-1151.
  • 5Desrois M, Clarke K, Lan C, et al. Upregulation of eNOS and un- changed energy metabolism in increased susceptibility of the aging type 2 diabetic GK rat heart to ischemic injury. Am J Physiol Heart Circ Physiol, 2010,299 : H1679-H1686.
  • 6Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemi- a : a delay of lethal cell injury in ischemic myocardium. Circulation, 1986,74 : 1124-1136.
  • 7Maslov LN, Lishmanov IuB, Oehgen P, et al. Preconditioning im- pact on coronary perfusion during ischemia and reperfusion of heart]. Ross Fiziol Zh Im I M Sechenova, 2012,98:433-448.
  • 8Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial in- jury by ischemic postconditioning during reperfusion: eornparison with ischemie preconditioning. Am J Physiol Heart Cite Physiol,2003,285:H579-H588.
  • 9Ovize M, Baxter GF, Di Lisa F, et al. Postconditioning and protec- tion from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res,2010,87:406-423.
  • 10Tsang A, Hausenloy D J, Mocanu MM, et al. Preconditioning the diabetic heart: the importance of Akt phosphorylation. Diabetes, 2005,54 : 2360-2364.

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