小剂量肝素佐治小儿支原体肺炎

Low-dose heparin in the adjunct treatment of children with mycoplasmal pneumonia

目的探讨小剂量肝素佐治小儿支原体肺炎的疗效。方法收集2010年1月-2012年1月本科室住院治疗的支原体肺炎患儿84例，随机数字表法分为对照组42例，治疗组42例。对照组给予阿奇霉素静脉滴注及口服治疗，治疗组加用小剂量肝素静脉滴注。比较两组患儿热退时间、咳嗽及肺部哕音消失时间、住院时间及疗效。结果与对照组比较，治疗组患儿热退时间、咳嗽及肺部哕音消失时间、住院时间均明显缩短[（5．93±0．79）d比（7．57±0．72）d，（7．10±0．91）d比（10．83±1．08）d，（9．15±3．26）d比（11．52±3．95）d，均P〈O．05]。治疗组显效41例（97．6％），有效1例（2．4％）；对照组显效35例（83．3％），有效7例（16．7％）。结论小剂量肝素辅佐治疗支原体肺炎疗效较好。

Objective To explore the efficacy of low-dose heparin in the adjunct treatment of children with mycoplasmal pneumonia. Methods Eighty-four inpatients in our department between January 2010 and January 2012 were recruited and allocated to control group （n=42） and treatment group （n=42） by random number table. Children in control group were treated with intravenous and oral azithromycin, treatment group received additional low-dose heparin intravenous injection based on control group. The duration of recovery from febrile, cough and crackles, the length of hospital stay and the efficacy in two groups were compared. Results Compared with control group, the treatment group presented significantly shorter duration of recovery from febrile, cough and crackles, and the length of hospital stay [ （5.93±.79） d vs （7.57±0.72） d, （7.10±.91） d vs （10.83±.08） d, （9.15±3.26） d vs （11.52±.95） d,all P〈0.05]. The treatment group had higher excellent effectiveness rate （41/42, 97.6% vs 35/42, 83.3% ） yet lower effectiveness rate （1/42, 2.4% vs 7/42, 16.7% ） as compared to control group. Conclusion Low-dose heparin should be regarded as a useful adjunct treatment of children with mycoplasmal pneumonia.