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上海浦东新区社区成人PON1基因多态性与慢性肾脏病的相关性

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摘要 慢性肾脏病(CKD)已成为近年全球关注的公共卫生问题。脂质代谢紊乱在CKD病程进展中起促进作用,对氧磷酶1(paraoxonase-1,PON1)是一种高密度脂蛋白相关的抗氧化物酶,其基因多态性性与酶活性、氧化应激、血管损伤及其共同通路上的某些表型(如血脂)相关。有研究发现,女性PON1基因rs662位点G—A突变与蛋白尿和肾小球滤过率(eGFR)下降相关。
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2013年第9期701-703,共3页 Chinese Journal of Nephrology
基金 上海市浦东新区科技发展基金项目(PKJ2011-Y08) 上海市重点建设项目(12GWZx0101)
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参考文献15

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