经典转化生长因子β/Smad信号和Wnt/β-catenin信号间的相互作用

Crosstalk between canonical TGF-β/Smad and Wnt /β-catenin signaling pathway

TGF-β信号通路是调节细胞生长和分化的的重要通路,此外还参与纤维化疾病发生和肿瘤发生发展的调控。Wnt信号通路是调节胚胎发育和肿瘤侵袭转移的重要通路。近10年来研究表明,这两条通路在调节胚胎发育、纤维化疾病发生以及肿瘤的演进等过程中共同发挥着重要作用,两者之间存在着密切联系,这两条通路存在Smad、轴蛋白(Axin)、蓬乱蛋白(Dvl)和β-连环蛋白(β-catenin)几个典型的相互作用的交叉点。本文着重阐述经典的TGF-β信号通路和Wnt信号通路在这几个交叉点的相互作用模式,以更好地应对纤维化疾病和肿瘤的进展。

TGF-β signaling pathway plays a central role in the signaling networks that control the growth,differentiation of the cell,and the initiation of fibrosis and cancer.Wnt signaling pathway is critical for the embryonic development and the invasion and migration of cancer cells.TGF-β signaling and Wnt signaling,both of which play an important role in regulating embryonic development,fibrotic disease and tumor progression,have a close relationship.Researches find several typical cross points between these two signaling systems,such as Smad,Axin,Dvl and β-catenin.In this review,we focus on the crosstalk between TGF-β signaling and Wnt signaling through these typical factors,intending to better understand the process of fibrosis and tumor progression.