摘要
离子通道是一类微孔细胞膜蛋白质,是维持机体生命活动的重要组分.其本身表达和活性的异常改变与肿瘤细胞的增殖和凋亡密切相关.本文系统阐述4种离子通道与肝细胞癌的关系及在其发生发展中的作用,提示离子通道有可能成为肝细胞癌的新的药物治疗靶点.
Ion channels are pore-forming membrane proteins which play regulatory roles in a variety of biological processes. Their abnormality in expression or activity has a close relationship with the proliferation and apoptosis of cancer cells. This article will describe the role of four ion channels in the development and progression of hepatocellular carcinoma. Our review suggests that ion channels might be a new therapeutic target for hepatocellular carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第29期3041-3046,共6页
World Chinese Journal of Digestology
关键词
离子通道
肝细胞癌
发生
发展
Ion channels
Hepatocellular carcinoma
Development
Progression