摘要
目的:探讨鼻咽癌放疗后放射性脑病的MRI特征。方法:收集2008年1月-2011年9月确诊为放射性脑病的65例鼻咽癌病例,分析其放射治疗方法,MRI及治疗效果。结果:65例放射性脑病患者76.9%有症状,中位潜伏时间为3年10个月,MRI显示81%的病灶分布在颞叶,11%的病灶位于脑干,8%在多叶。33例经治疗后多次复查MRI结果表现不一。结论:放射性脑病的发生与放疗总剂量、分割剂量等呈正相关,其发生部位与照射野的设计有关,多数在放疗后2-3年发生,其临床表现各异,主要与损伤发生部位有关,MRI是目前最优的检查方法。
Objective:To explore the characteristics of MRI of radiation encephalopathy (REP) after radiotherapy in nasopharyngeal carcinoma (NPC).Methods:All 65 cases of NPC with diagnosis of REP from January 2008 to September 2011 were analyzed retrospectively.All patients were diagnosed on grounds of radiotherapy,MRI and therapeutic efficacy.Results:76.9% patients had symptoms,and the median latency period was 3 years and 10 months.The MRI showed that 81% of the radiation injury lesions situated in the temporal lobes,11% of the lesions situated in brain stems,and 8% of the lesions situated in multi-lobes,33 patients showed multiple manifestations in MRI.Conclusion:Radiation injury of brain in NPC patients after radiotherapy are related to total dose,fraction dose and field design.The latent period of this disease was from 2 to 3 years.MRI is the most effective mean of REP for diagnosis.
出处
《现代肿瘤医学》
CAS
2013年第11期2432-2434,共3页
Journal of Modern Oncology
基金
广西梧州市科学研究与技术开发计划项目(编号:200702019)
关键词
鼻咽癌
放疗
放射性脑病
MRI
nasopharyngeal carcinoma
radiotherapy
radiation encephalopathy
MRI