稳心颗粒联合美托洛尔治疗老年人冠心病心律失常的临床疗效观察

Clinical effect of Wenxin granule combined with metoproloi on arrhythmia in elderly patients with coronary heart disease

目的探讨稳心颗粒联合美托洛尔治疗老年人冠心病心律失常的疗效及其安全性。方法回顾性分析186例老年人冠心病心律失常临床资料，根据药物治疗方案分为稳心颗粒组62例；美托洛尔组60例；联合组64例采用稳心颗粒联合美托洛尔治疗。观察人选患者临床治疗效果及其不良反应。结果联合组显效率和总有效率〈53．1％（34例）、93．8％（60例）]高于稳心颗粒组[32．3％（20例）、40．3％（25例）]、美托洛尔组〈30．0％（18例）、40．0％（24例），Y。值分别为10．736、11．342，均P〈0．053。联合组显效率和总有效率较稳心颗粒组和美托洛尔组高（均P〈0．05）。3组不良反应发生率分别为4．8％（3／62）、8．3％（5／60）和8．3％（5／64），均P〉O．05。结论稳心颗粒和美托洛尔的联合应用治疗老年冠心病心律失常，减少期前收缩次数，安全性好。

Objective To explore the clinical effect and safety of Wenxin granule combined with metoprolol on arrhythmia in elderly patients with coronary heart disease （CHD）. Methods 186 elderly CHD patients with arrhythmia were divided into 3 groups according to therapy： group A （n= 62, treated with Wenxin granule）, group B （n=60, treated with metoprolol） and group C （n=64, treated with Wenxin granule plus metoprolol ）. Clinical effect and adverse effect were retrospectively analyzed. Results The excellence rate and total efficiency rate were higher in group C than group A and B [53.1% （34 cases） vs. 32.3%/0 （20 cases）, 30.0% （18 cases） 93.8% （60 cases） vs. 40.3% （25 cases）, 40.0% （24 cases） respectively, all P〈0. 051. There were no significant differences in the incidence of adverse effect in the 3 groups4.8% （3/62）, 8.3% （5/60） vs. 8.3% （5/64）, all P 〈0. 051. Conclusions Wenxin granule combined with metoprolol improves clinical effect, decreases premature beat and has a better safety for elderly CHD patients with arrhythmia, which is worthy of clinical application.