老年男性骨密度与骨代谢指标分析

Analysis of bone mineral density and bone metabolic biochemical markers in 220 elderly men

目的观察老年男性骨密度与骨代谢特点。方法人选220例老年男性住院患者，根据年龄分为三组，测量骨密度及甲状旁腺激素（PTH）、骨钙素（BGP）、25-羟维生素D（25-OHVD）等骨代谢指标。结果老年男性随着年龄增长，骨质疏松患病率增高，65～74岁组、75～84岁组及85～94岁组的骨质疏松患病率分别为6．8％、12．0％与22．9％（x2=7．72，P〈0．05）。老年男性骨代谢特点是，PTH随年龄增长呈上升趋势（F=4．986，P〈0．05），BGP、25-OHVD随年龄增长呈下降趋势（F=4．986，3．245，5．997，P〈0．05），老年人中BGP、25-OHVD水平普遍较低。结论老年男性骨质疏松患病率高，骨代谢可以作为骨质疏松风险评估的辅助指标，有助于原发性骨质疏松的早期诊断。

Objective To study the characteristics of bone mineral density and bone metabolism in elderly men. Methods 220 male elderly hospitalized patients were selected and divided into three groups according to age： 65-74 years group, 75-84 years group and 85-94 years group. Bone mineral density and bone metabolic biochemical makers including serum parathyroid hormone （PTH）, bone gla-protein （BGP） and 25-dihydroxy vitamin D （25-OH VD） were detected. Results The prevalence of osteoporosis was increased along with ageing in three groups （6.8%, 12.0% vs. 22.9%, respectively, F=4. 986,P〈0.05）. The characteristics of bone metabolism showed that serum PTH level was increased and serum levels of BGP, 25-OH VD were decreased along with ageing （F= 4. 986,3. 245,5. 997,all P〈0.05）, and the levels of BGP, 25-OH VD were generally decreased in elderly men. Conclusions The prevalence of osteoporosis is high in elderly men. Bone metabolism can be used as the auxiliary index for osteoporosis risk assessment, which is helpful for the early diagnosis of primary osteoporosis.