摘要
Hydrophobic fluorescence:Tan and his colleagues recently introduced a brand new chemotype of environment-sensitive fluorescent turn-on probes to detect the hydrophobic ligand-binding domain by using SBD fluorophore.The design strategy described in this report generalized the environment sensitivity turn-on mechanism to recognize a specific protein,which provides a robust breakthrough for interchanging fluorescence in conventional small-molecule fluorescent imaging.
Hydrophobic fluorescence： Tan and his colleagues recently introduced a brand new chemotype of environment-sensitive fluorescent turn-on probes to detect the hydrophobic ligand-binding domain by using SBD fluorophore. The design strategy described in this report generalized the environment sensitivity turn-on mechanism to recognize a specific protein, which provides a robust breakthrough for interchanging fluorescence in conventional small-molecule fluorescent imaging.
基金
supported by the National Natural Science Foundation of China (81370085)
the Program of New Century Excellent Talents in University (NCET-11-0306)
the Fok Ying Tong Education Foundation (122036)
the Shandong Natural Science Foundation (JQ201019)
the Independent Innovation Foundation of Shandong University (2010JQ005 and 2012JC002).
