河南漯河地区中老年人群类风湿关节炎流行病学调查

Epidemiology of rheumatoid arthritis in middle-aged and elderly population in Luohe City, Henan Province

目的了解河南漯河地区中老年人群类风湿关节炎患病相关情况。方法采取两阶段整群抽样的方法对漯河地区中老年进行问卷调查以及化验室检测，依据2010年美国和欧洲的抗风湿病联盟提出的类风湿关节炎分类标准进行评估类风湿关节炎患病情况。结果共调查居民8610人，应答率为96．10％。关节评分0、1、2、3及5分的患病率分别为13．62％、7．57％、2．79％、1．87％和0．23％。血红细胞沉降率（ESR）和C反应蛋白（CRP）升高的患病率分别为17．48％、14．27％，类风湿因子（RF）和抗环瓜氨酸肽抗体（抗CCP抗体）低滴度阳性和高滴度阳性率分别为6．62％、1．96％和5．48％、1．55％。共确诊类风湿关节炎63例，类风湿关节炎的粗患病率为0．76％，标化患病率为0．71％，女性患病1．02％，男性0．39％，两者比较P〈0．01。该人群类风湿关节炎知晓率为74．60％，治疗率和控制率分别为71．43％和18．57％。结论漯河市中老年人群类风湿关节炎的患病情况不容乐观，女性高于男性，知晓率治疗率均较低。

Objective To explore the local prevalence of rheumatoid arthritis （RA） among the middle-aged and elderly population. Methods A total of 8610 residents were recruited for a two-stage cluster sampling survey through a questionnaire of RA according to 2010 ACR/EULAR classification criteria. Physical examinations and blood tests were performed. Results The responding rate was 96. 10%. Joint scoreO, 1, 2, 3, 5 was detected in 13.62%, 7.57%, 2. 79%, 1.87% and 0.23% of subjects. The prevalence of joint score O, 1, 2, 3, 5 was 13.62%, 7. 57%, 2. 79%, 1.87% and 0. 23%. The rate was 17.48% and 14. 27% for elevated levels of erythrocyte sedimentation rate （ESR） and C-reactive protein （ CRP）, 6. 62%, 1.96% and 5.48%, 1.55% for low titer and high titer rheumatoid factor （RF） and anti- cyclic citrullinated peptide （anti-CCP） positive antibody. And 63 RA cases were confirmed. The crude prevalence was 0. 76% and 0. 71% for standardized prevalence. Compared to males, females had a higher prevalence of RA （ 1.02% vs 0. 39%, P 〈 0. 01 ）. In the population, the awareness rate was 74. 60%, cure rate 71.43% and control rate 18.57% respectively. Conclusion The local prevalence of RA in elderly females is higher than that in males. And the treatment and awareness rates are also low.