胆囊胆汁癌胚抗原诊断大肠癌肝转移的临床意义

The Clinical Signification of CEA Value of Cholecytic Bile for Diagnosis of Colonic Cancer Metastased to liver

目的 探讨胆囊胆汁癌胚抗原 (CEA)值诊断大肠癌肝转移的临床价值。方法 应用竞争放射免疫分析法共测定胆囊胆汁及同期血清CEA值 75例。共分为三组 :A组 (大肠癌组 ) 34例、B组 (术后肝转移组 ) 11例、C组 (良性疾病组 )为对照组 30例。胆汁标本于术中细针穿刺胆囊抽取 5ml ,血清标本于术晨采集静脉血 2ml。结果 胆汁CEA测定结果 :A组均值 ( 173 2± 2 5)ng ml;B组均值 ( 752± 117)ng ml;C组均值 ( 4 1 3± 2 8)ng ml。经统计学处理 ,A、B与C组比较有显著性差异P <0 0 1,A与B组比较有显著性差异P <0 0 1。血清CEA测定结果 :A组均值 ( 17 3± 2 7)ng ml;B组均值 ( 19 5± 4 3)ng ml ;C组均值 ( 11 3± 1 4 )ng ml。经统计学处理 ,A、B与C组比较有明显差异P <0 0 5。A与B组比较无明显差异P >0 0 5。结论 胆囊胆汁CEA值 >640ng ml时对诊断大肠癌肝转移有一定临床意义。

Objective It explored the carcino-embryonic antigen(CEA)values of cholecystic bile to diagnose hepatic metastasis of the colonic cancer and to estimate its clinical significance.Methods Utilized competitive radio-immunoassay surveyed CEA simultaneously both cholecystic bile and serum of 75 cases.These cases divided into three groups.Group A(colonic cancer group)34 cases,Group B(postoperatively hepatic metastases of colonic carcinoma group)11 cases,Group C (Begin disease group)for controlled group 30 cases,the bile specimen adopted intraoperatively to puncture cholecyst with a fine needle aspirated 5ml,the serum specimen adopted 2ml blood on the morning of preoperation for CEA test.Results CEA values of the bile were:Group A,average value(173.2±25)ng/ml.Group B,average value(752±117)ng/ml.Group C,average value (41.3±2.8)ng/ml.Statistic showed Group A and group B versus group C had obvious difference P <0.01,Groups A versus Group B had also obvious difference P <0.01.CEA values of serums were:Groups C average values (11.3±1.4)ng/ml.Groups A average values(17.3±2.7)ng/ml.Groups B average values(19.5±4.3)ng/ml.Statistic manifested comparison between group A and group C had obvious difference P <0.05,but there was no obvious difference between group A and group B P >0.05.Conclusion The data of this series demonstratde CEA values of cholecystic bile>640ng/ml for dia-gnosis of colonic cancer metastased to liver,there was an important clinical signification.