羟基喜树碱膀胱灌注预防膀胱癌术后复发

Intravesical Instillation of HCPT to Prevent Recurrence after Surgery for Bladder Cancer

目的 评估膀胱灌注羟基喜树碱预防膀胱癌术后复发的疗效。方法 应用羟基喜树碱膀胱灌注预防膀胱癌术后复发并与MMC进行随机对照观察。结果 羟基喜树碱组治疗 2 3例 ,随访 6～ 36个月 ,复发 3例 ,复发率为 13 0 %。而MMC组治疗 2 2例 ,随访 7～ 36个月 ,复发 4例 ,复发率为 18 2 %。结论 提示HCPT的疗效与MMC相仿 ,而副作用明显减少 ,认为羟基喜树碱是目前预防膀胱癌术后复发较理想的药物之一。

Objective To evalute the results of intravesical HCPT instillation to prevent recurrence after surgery for bladder cancer.Methods A randomized and placebo-controlled trial on intravesical HCPT instillation versus MMC therapy for recurrence prevention in post operative bladder cancer patients was carried out.Results Twnty-three patients were treated with HCPT with.23 followed for 6 to 36 months.Three patients developed recurrence,recurrent rate was 13.0%.Twenty-two.patients were treated with MMC with 22 followed for 7 to 36 months.Four patients developed recurrence,recurrent rate was 18.2%.Conclusion There is little different between HCPT with MMC on results.but,HCPT has milder side effects.HCPT is believed to be one of the effective drugs in preventing bladder cancer recurrence after surgery.