IVF获卵数、全胚冷冻与体外受精胚胎移植妊娠结局的关系

Outcomes of first freezing-thaw cycle of total embryo freezing IVF in difference oocyte group avoiding OHSS

目的探讨控制超排卵（COH）中获卵数对体外受精一胚胎移植（IVF—ET）妊娠结局的影响，及为避免重度OHSS全胚冷冻的效果。方法接受常规IVF助孕治疗的不孕症患者358例（除外ICSI，Half—ICSI，Re—ICSI）。根据获卵数不同分为3组，其中获卵数1～10者122例（I组），获卵数11～20者183例（II组），获卵数〉20者53例（Ⅲ组）；358例中发生OHSS48例全胚冷冻，其中I组无全胚冷冻，Ⅱ组全胚冷冻28例，Ⅲ组全胚冷冻20例。结果全胚冷冻组与新鲜移植组比较：年龄及优胚率无明显差异，着床率及临床妊娠率无明显差异；新鲜移植第Ⅲ组着床率及临床妊娠率低于全胚冷冻第Ⅲ组，差异有显著性。结论OHSS时全胚冷冻保证了妊娠结局，尤其对获卵数〉20的患者有利。

Objective ： To compare outcomes of first embryo transfer in fresh and freezing - thaw cycle of total embryo freezing IVF in difference oocyte group avoiding OHSS. Methods ： Conventional IVF - ET patients divided into three groups depending on the number of oocytes ： 1 - 10 （ group I ） 122 patients, 11 - 20 （ group II ） 183 patients, 〉 20 （ group III ） 53 patients. There are 48 cases of OHSS occurs and total embryo freeze in 358 patients, group I had 0 cases, group i128 cases, group m had 20 cases, number of oocytes retrieved, fertilization rate, embryo survival after thaw, number of embryos transferred, implantation rate, PR, LBR, and multiple gestations were analysized. Results ： Comparing rates of age and embryo, implantation and clinical pregnancy of fresh transfer embryo group and total embryo frozen group, there are no significantly different. Fresh implantation and clinical pregnancy rates lowest III group embryo freezing part III implantation rate and clinical pregnancy rates, differences are significant. Conclusions： Pregnancy out- come of OHSS embryo freeze is good, especially for 〉 20 oocyte number.