从不同角度探讨男性不育的原因

Probe into causes of male infertility from different angles

全世界有10%-15%的夫妻在结婚一年内未孕。这些病例中,男性因素不育至少占一半。男性不育的原因很多,包括身体发育异常、免疫原因、精子畸形、染色体异常、Y染色体微缺失、基因缺失、基因单核苷酸多态性以及其他原因。本文综述男性不育的每一种因素,其目的是为了帮助临床医师对不育男性病人诊断、遗传咨询以及进一步开展辅助生殖工作。

Approximately 10% - 15% of couples worldwide are unsuccessful in achieving a pregnancy within 1 year ＇,after marriage. At least 50% of these cases were associated with the male factor. Male infertility can be caused by different factors including physical defermities, immunelogic causes, abnormal forms of spermatozoa, chromosomal abnormalities, Y - chromosome micro - deletion, gene deletion, single nucleotide polymorphisms of genes and other factors. This article reviews the factors associated with male infertility and the objective is to help the clinicians for nkale infertility diagnosis, genetic eounsceling of the infertile male and the further reproductive assistance.