接骨木中1个新的降三萜成分

A new nortriterpenoid from Sambucus williamsii

目的研究接骨木Sambucus williamsii茎枝的化学成分。方法采用D-101大孔吸附树脂、硅胶、ODS、Sephadex LH-20、Toyopearl HW-40和RP-HPLC等色谱分离手段进行分离纯化,根据化合物的理化性质和波谱数据鉴定其结构。结果从接骨木茎枝60%乙醇提取物中分离得到6个化合物,分别鉴定为23-羟基-3-羰基-28-去甲基-12,16-二烯齐墩果烷(1)、3-羰基齐墩果酸(2)、齐墩果酸(3)、白桦酸(4)、棕榈酸(5)、正二十八醇(6)。结论化合物1为1个新的降三萜类化合物,命名为接骨木烷A;化合物2和6为首次从该植物中分离得到。

Objective To study the chemical constituents in 60% ethanol extract from the stems of Sambucus williamsii. Methods Six compounds were isolated and purified by macroporous resin D-101, silica gel, Sephadex LH-20, Toyopearl HW-40, ODS column chromatographies, and RP-HPLC. Results Their structures were elucidated by spectroscopic methods and identified as 23-hydroxy- 3-oxo-28-nor-12, 16-dien oleanane （1）, 3-oxo-oleanolic acid （2）, oleanolic acid （3）, betulinic acid （4）, palmitic acid （5）, and 1-octacosanol （6）. Conclusion Compound I is a new nortriterpenoid named sambucusan A. Compounds 2 and 6 are isolated from this plant for the first time.