住院精神分裂症患者药物使用现况调查

Current situation of drug utilization in schizophrenia inpatients

目的调查2013年5月在上海交通大学医学院附属精神卫生中心住院的精神分裂症患者药物使用情况。方法本次研究为横断面研究，以2013年5月22日为时点调查日，对我院802例精神分裂症住院患者使用自制调查表进行药物使用的现况调查。结果（1）单一使用抗精神病药物患者比例为43．45％。（2）抗精神病药物使用频度前5位：氯氮平421例（52．56％），奥氮平225例（28．09％），利培酮196例（24．47％），阿立派唑158例（19．73％），奎硫平126例（15．73％）。（3）精神分裂症患者中合并糖尿病的比例为21．70％，且年龄因素、是否使用氯氮平治疗与糖尿病的发生有相关性。（4）精神分裂症患者中合并高血压的比例为33．04％，且年龄因素与高血压的发生有相关性。结论我院单一用药比例低，氯氮平的使用率高，抗精神病药物的治疗仍需进一步规范。精神分裂症患者中合并糖尿病、高血压的比例高，年龄因素可增加糖尿病、高血压的发生率，服用氯氮平可增加糖尿病的发生率。

Objective To investigate the current situation of drug utilization in schizophrenia inpa- tients. Methods As a cross--sectional study, this study began from May 22, 2013. The self--survey was used to investigate the utilization of drug in schizophrenia inpatient. Results There were 43. 450%） patients in single drug therapy, APD most frequently prescribed was clozapine （52.56%）, subsequently were olanzapine （20.09%）, risperidone（24.47%））, aripiprazole （19.73%）, quetiapine （15.73%）. A- mong 802 schizophrenic patients, 174 caries（21.70%）） suffered from diabetes mellitus and related to age and use of clozapine. There are 265 cades（33. 04%） suffered from hypertension and related to age. Con- clusions In our hospital, the proportion of using single drug is low, and clozapine is high. Antipsychotic treatment needs further specification. The prevalence of diabetes mellitus or hypertension in this popula tion was higher than that in general population, incidence of diabetes mellitus is positively related with age and administration of clozapine, incidence of hypertension is positively related to age.