Synthesis and Preliminary Evaluation of 1-[^18F]Fluoro-1-deoxy-2,5-anhydro-D-mannitol as a PET Radiotracer for Breast Cancer Imaging
Synthesis and Preliminary Evaluation of 1-[^18F]Fluoro-1-deoxy-2,5-anhydro-D-mannitol as a PET Radiotracer for Breast Cancer Imaging
摘要
1-[18F ] Fluoro-1-deoxy-2,5-anhydro-D-mannitol (3， 18F-FDAM ) 在从 2,5-anhydro-D-mannitol (2,5AM ) 开始的 6 步被综合了并且为 MCF-7 胸肿瘤的宠物成像作为新 radiotracer 评估了。宠物成像学习的结果证明 3 与正常的胸织物比较由胸肿瘤显示了稍微更高的举起，暗示基于指向的宠物 radiotracers 的开发的可能性果糖 transporters。
1-[^18F]Fluoro-l-deoxy-2,5-anhydro-D-mannitol （3, ^18F-FDAM） has been synthesized in 6 steps starting from 2,5-anhydro-D-mannitol （2,5-AM） and evaluated as a new radiotracer for PET imaging of MCF-7 breast tumor. The result of PET imaging study showed that 3 displayed a slightly higher uptake by breast tumor in comparison with the normal breast tissue, implying the possibility of development of PET radiotraeers based on targeting fructose transporters.
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