原发性高血压病患者血压变异性与脑梗死的关系研究

Relationship of BP Variability to Cerebral Infarction in Essential Hypertension Patients

目的分析原发性高血压病患者血压变异性与脑梗死的关系。方法选择2011年1月—2012年7月在新疆石河子大学医学院第一附属医院心内科住院的189例原发性高血压病患者为研究对象,根据有无脑梗死分为原发性高血压病无脑梗死者65例(A组)、原发性高血压病合并无症状脑梗死者67例(B组)和原发性高血压病合并有症状脑梗死者57例(C组),均行24 h动态血压监测,比较3组患者的一般资料、平均血压及血压变异性。结果 B、C两组患者年龄均高于A组,差异有统计学意义(P<0.05)。B、C两组患者的24 h平均收缩压(24 hSBP)、24 h平均舒张压(24 hDBP)、日间平均收缩压(dSBP)、日间平均舒张压(dDBP)、夜间平均收缩压(nSBP)、夜间平均舒张压(nDBP)均高于A组,差异有统计学意义(P<0.05)。B、C两组患者的24 h平均收缩压变异性(24 hSBPV)、日间平均收缩压变异性(dSBPV)均高于A组,差异有统计学意义(P<0.05)。结论年龄较大的原发性高血压病患者平均血压和24 hSBPV、dSBPV升高是并发脑梗死的危险信号,临床应引起注意。

Objective To analyze the relationship of blood pressure （BP） Variablity to cerebral infarction （CI）. Methods A total of 189 patients with essential hypertension （EH） hospitalized from January 2011 to July 2012 were divided in- to groups A （with EH without CI, n = 65 ）, B （with EH combined with asymptomatic CI, n = 67 ）, C （with EH combined with symptomatic CI, n = 57 ）. The 24 h ambulatory BP monitoring was used , and general information, average BP and BP var- iability compared. Results The average age was higher in groups B, C than in group A, the difference was significant （ P 〈 0. 05）. The 24 h systolic blood pressure （SBP）, 24 h diastolic blood pressure （DBP）, daytime SBP, daytime DBP, night- time SBP, nighttime DBP were higher in groups B, C than in group A, the difference was significant （ P 〈 0. 05 ）. The 24 hSBP variability （24 hSBPV）, daytime SBP variability （dSBPV） were higher in groups B, C than in group ＇A （ P 〈 0. 05 ）. Conclusion Average BP,24 hSBPV, dSBPV are dangerous signals for elderly EH patients, which is should be paid attention to.