香港中文大学预测指数对行放射治疗的原发性肝癌患者预后的评估价值

Prognostic Value of CUPI for Liver Cancer Patients Receiving Radiotherapy

目的评价香港中文大学预测指数(CUPI)对行放射治疗的原发性肝癌患者预后的评估价值。方法选择2004年5月—2011年5月在株洲市中心医院行三维适形放射治疗的原发性肝癌患者112例,根据CUPI分为低危组77例,中危组32例,高危组3例。绘制Kaplan-Meier生存曲线并进行log-rank检验。结果所有患者中位生存期为14.0个月〔95%CI(9.7,18.3)〕,1年、2年、3年、4年和5年生存率分别为56%、36%、33%、25%和21%。低危组中位生存期为20.0个月〔95%CI(15.3,27.1)〕,中危组为8.0个月〔95%CI(6.3,10.0)〕,高危组为4.0个月〔95%CI(1.7,6.1)〕。log-rank检验结果显示,低危组与中危组、中危组与高危组生存曲线比较,差异均有统计学意义(P值分别为0.002和0.010)。结论 CUPI对接受放射治疗的原发性肝癌患者的预后有较好的评估价值,有助于筛选适宜放射治疗的患者。

Objective To evaluate the prognostic value of Chinese University Prognostic Index （CUPI） for liver cancer （LC） patients treated by radiotherapy. Methods A total of 112 LC patients received three dimensional conformal radia- tion therapy （CRT） in this hospital from May 2004 to May 2011 were divided, based on CUPI, into groups low -risk （n = 77 ）, medium - risk （ n = 32）, high - risk （ n = 3 ）. Kaplan - Meier survival curves were plotted and log - rank test carried out. Results Median survival time was 14.0 months [95%CI （9.7, 18.3）~, 1 -, 2-, 3-, 4-, 5-year survival rates were 56% , 36% , 33%, 25%, 21%, respectively. Median survival time was 20. 0 months in low -risk group [95%C1 15.3, 27.1）3, 8. 0 months in medium - risk group [95%CI （6.3, 10.0）3, 4.0 months in high-risk group [95%CI 1.7, 6. 1 ） 1. By log - rank test, there was significant difference in survival curve between groups low - risk and medium - risk P = 0. 002）, between groups medium - risk and high - risk （ P = 0. 010）. Conclusion CUPI, having great predictive values m prognosis of LC patients treated by radiotherapy, helps select patients suitable for radiotherapy