丁苯肽对急性脑梗死后认知功能和生活质量的改善作用

Improving effect of Butylphthalide on cognitive function and life quality in patients after suffering acute cerebral infarction

目的探讨丁苯肽对急性脑梗死后认知功能和生活质量的改善作用。方法选择80例急性脑梗死后认知功能障碍患者,随机分为观察组和对照组。两组患者均酌情予以控制血压、血糖和血脂,血小板聚集和营养脑细胞等基础治疗。观察组患者加用丁苯肽胶囊200 mg/次,4次/d,连用8周。对照组患者加用尼莫同片30 mg/次,3次/d,连用8周。观察并比较两组患者治疗前后认知功能和生活质量的变化。结果治疗8周后,两组患者MMSE评分、WMS评分和MOCA评分[(23.72±4.58)、(38.25±5.96)、(24.06±5.19)、(27.45±4.92)、(44.64±6.02)、(27.92±5.35)分]均较治疗前[(18.97±4.45)、(33.51±5.85)、(19.31±4.19)、(19.03±4.37)、(33.94±6.17)、(18.97±4.47)分]明显上升(t=2.47、2.25、2.44、3.05、2.82、3.17,P<0.05或P<0.01),且观察组上升值明显高于对照组(t=2.26、2.29、2.23,均P<0.05);同时两组患者日常生活、物质功能、社会功能和心理功能评分[(34.64±5.16)、(21.92±3.94)、(19.14±4.47)、(21.36±3.89)、(29.12±4.93)、(17.13±3.86)、(15.06±3.65)、(16.97±3.72)分]均较治疗前[(39.83±6.14)、(26.82±4.84)、(24.07±5.01)、(26.18±4.12)、(40.18±5.87)、(27.16±4.75)、(23.85±4.82)、(25.91±3.93)分]明显下降(t=2.30、2.40、2.47、2.44、2.82、3.27、2.31、3.12,P<0.05或P<0.01),且观察组患者的下降值明显高于对照组(t=2.29、2.38、2.39、2.36,均P<0.05)。结论丁苯肽能明显改善急性脑梗死后患者的认知功能障碍,延缓患者认知功能下降的速度,有利于提高患者生活质量,从而改善患者的预后。

Objective To discuss Butylphthalide＇s improving effect for cognitive function and life quality in patients after suffering acute cerebral infarction. Methods 80 cases of cognitive dysfunction patients after suffering acute cerebral infarction were selected and divided into observation group and control group. The patients in two groups were given basic treatment like the control of blood pressure, blood sugar and blood fat, platelet aggregation （PA）, brain ceils nutrition and etc. as needed. The patients in observation group were given 200 mg Bu.tylphthalide Soft Capsules per time, 4 times daily for 8 weeks. The patients in control group were given 30 mg Nimodipine three times daily for 8 weeks. The changes of cognitive function and life quality of patients in two groups before and after medical treatment were observed and compared. Results After 8 weeks＇ medical treatment, the MMSE, WMS and MOCA scores of patients in two groups [（23.72±4.58）, （38.25±5.96）, （24.06± 5.19）, （27.45±4.92）, （44.64±6.02）, （27.92±5.35） points] rose obviously than before [（18.97±4.45）, （33.51±5.85）, （19.31±4.19）, （19.03±4.37）, （33.94±6.17）, （18.97±4.47） points] （t = 2.47, 2.25, 2.44, 3.05, 2.82, 3.17, P 〈 0.05 or P 〈 0.01）, and the rising rate in observation group was much higher than that in control group （t = 2.26, 2.29, 2.23, all P 〈 0.05）. Meanwhile, the scores of daily life, material function, society function and psychology function [（34.64±5.16）, （21.92±3.94）, （19.14±4.47）, （21.36±3.89）, （29.12±4.93）, （17.13±3.86）, （15.06±3.65）, （16.97±3.72） points] declined obviously than before [（39.83±6.14）, （26.82±4.84）, （24.07±5.01）, （26.18±4.12）, （40.18±5.87）, （27.16±4.75）, （23.85±4.82）, （25.91±3.93） points] （t = 2.30, 2.40, 2.47, 2.44, 2.82, 3.27, 2.31, 3.12, P 〈 0.05 or P 〈 0.01）. Meanwhile, the declining rate of patients in observation group was much higher than that in control group （t = 2.29, 2.38, 2.39, 2.36, all P 〈 0.05）. Conclusion Butylphthalide Soft Capsules can obvi- ously improve the cognitive dysfunction patients after suffering acute cerebral infarction, postpone the descent speed of cognitive function of patients, which is propitious to improve the life quality and prognosis of patients.