β_2肾上腺素能受体基因多态性和支气管哮喘关系的最新研究进展被引量：6

Recent develpment between β_2-adrenergic receptor polymorphisms and asthma

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摘要过去有关β2肾上腺素能受体基因(ADRB2)多态性的研究重点集中在编码区的多态性,这些多态性可能与哮喘的发生、表型及治疗反应相关,但是研究结果不完全一致。近年来大量研究发现,不仅仅是编码区,5′和3′非翻译区的多态性同样能改变β2肾上腺素能受体(β2AR)的功能并影响着哮喘的治疗反应等,应同时对β2-AR基因中所有的变异即完整的单倍型进行识别和分析。现综述近来对ADRB2基因编码区、5′和3′非翻译区多态性的研究新进展,特别是3′非翻译区poly-C重复序列的长度的变异可能对哮喘患者的肺功能和对β2AR激动剂的治疗反应具有重要作用。 Previous studies of association of beta 2 adrenergic receptor gene （β2-AR） with bronchial asthma was focused in the coding region polymorphisms, these polymorphisms may be associated with the asthmatic suseeptivity, phenotype and response to treatment. But there are many inconsistent results,and these differences could not be fully explained by β2-AR gene coding region and the 5＇untranslated region polymorphism. In recent years a large number of studies have found not only the coding region,5＇and 3＇ untranslated region polymorphisms can also change the β2-AR function and affect treatment response in asthma. All variants that complete haplotypes on theβ2-AR gene should be identified and analyzed. This article reviews the recent development ofβ2 AR gene coding region, 5＇and 3＇ untranslated region polymorphisms,espeeially the g＇untranslated region of poly-C repeat length variation on patients with asthma plays an important role on pulmonary function and β2-AR agonist treatment response.

作者陈慧芬张德平邱玉英

机构地区南京医科大学鼓楼临床学院呼吸科南京医科大学

出处《中华哮喘杂志（电子版）》 CAS 2013年第5期40-44,共5页 Chinese Journal of Asthma(Electronic Version)

关键词哮喘 Β2肾上腺素能受体多态性单倍型 3’非翻译区poly-C重复序列 Asthma β2- adrenergic receptor Polymorphisms Haplotype untranslated regionpoly-C repeat sequence

分类号 R541.6 [医药卫生—心血管疾病]

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